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- Season 2 overviewSep 22, 2016-May 11, 201723 episodesSeason 2 episodes23. Love Hurts May 11, 2017
- A new doctor arrives at Chicago Med; Halstead and Manning try to diagnose a Syrian refugee.
- 22. White Butterflies May 4, 2017
- Rhodes challenges Charles and other hospital staff over treatment for Robin; Goodwin helps a friend.
- 21. Deliver Us Apr 27, 2017
- A mother is desperate to help her daughter beat cancer; Dr. Choi puts pressure on Noah.
- 20. Generation Gap Apr 13, 2017
- Dr. Charles gets involved when his daughter's strange behavior continues to intensify.
- 19. CTRL ALT Apr 6, 2017
- Doctors work without the aid of technology after a hacker shuts down the hospital computer system.
- 18. Lesson Learned Mar 30, 2017
- Will confronts a moral decision when his former teacher faces a life-threatening disease.
- 17. Monday Mourning Mar 16, 2017
- The staff deals with a team member's suicide; a patient experiences stroke symptoms.
- 16. Prisoner's Dilemma Mar 9, 2017
- A troubled teen in a psychiatric facility contacts Reese; a comatose woman is found to be pregnant.
- 15. Lose Yourself Mar 2, 2017
- A trauma patient's survival becomes a media sensation; April befriends a young heart patient.
- 14. Cold Front Feb 16, 2017
- A multi-car accident occurs during a blizzard; Rhodes and Latham make difficult decisions in triage.
- 13. Theseus' Ship Feb 9, 2017
- A young patient and his father force Dr. Manning to make a difficult decision.
- 12. Mirror Mirror Feb 2, 2017
- A girl's rapidly changing symptoms have everyone perplexed; a teenage tough guy is in distress.
- 11. Graveyard Shift Jan 19, 2017
- Dr. Reese deals with having to pronounce several patients dead; April is told to slow down.
- 10. Heart Matters Jan 12, 2017
- A heart transplant patient is in a car crash; the officer who arrested Maggie has a serious injury.
- 9. Uncharted Territory Jan 5, 2017
- Dr. Charles is tasked with evaluating a patient as a possible heart recipient.
- 8. Free Will Nov 10, 2016
- Halstead and Manning deal with two feuding brothers, one of which is in dire need of a kidney.
- 7. Inherent Bias Nov 3, 2016
- Goodwin reunites with her childhood sweetheart; Dr. Halstead works to get his finances in order.
- 6. Alternative Medicine Oct 27, 2016
- A young cancer patient fails to tell her parents about her condition; Reese helps a troubled man.
- 5. Extreme Measures Oct 20, 2016
- Victims need help after a car crash at the Chicago Marathon; Dr. Choi treats a malnourished woman.
- 4. Brother's Keeper Oct 13, 2016
- Dr. Charles' epidemiologist daughter consults on a rare infection.
- 3. Natural History Oct 6, 2016
- An Indonesian man who doesn't speak English arrives at the hospital with a mysterious illness.
- 2. Win Loss Sep 29, 2016
- Two cases involving sick babies may be connected; a homeless man enlightens Halstead and Charles.
- 1. Soul Care Sep 22, 2016
- Dr. Rhodes begins his cardiothoracic surgery fellowship; Dr. Choi begins his life as chief resident.