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- OverviewNov 17, 2015-May 17, 201618 episodesEpisodes18. Timing May 17, 2016
- Dr. Rhodes cares for Dr. Downey while Goodwin deals with personal issues.
- 17. Withdrawal May 10, 2016
- April and Dr. Halstead can't agree on how to treat a homeless alcoholic with a broken leg.
- 16. Disorder May 3, 2016
- Rhodes and Downey are at odds over a patient's heart surgery; a hoarder's home presents a challenge.
- 15. Inheritance Apr 26, 2016
- A patient refuses medication for her pain; Dr. Halstead treats a former high school classmate.
- 14. Hearts Apr 19, 2016
- An erratic patient presents an unusual case for Dr. Choi; a boy's injury concerns Dr. Manning.
- 13. Us Apr 5, 2016
- A husband has an unusual request after the death of his wife; a patient wants his arm amputated.
- 12. Guilty Mar 29, 2016
- Nurse Lockwood is arrested for not doing a blood test; concerns are raised over a baby's injuries.
- 11. Intervention Feb 22, 2016
- A patient with a life-threatening condition makes a decision that puts Rhodes and Choi at odds.
- 10. Clarity Feb 16, 2016
- A 9/11 hero with pulmonary fibrosis needs a new set of lungs; a teenage hockey player is injured.
- 9. Choices Feb 9, 2016
- Dr. Halstead's career is in jeopardy when he disregards a do not resuscitate order.
- 8. Reunion Feb 2, 2016
- Dr. Manning helps treat a teenager with an extensive history of medical issues; a budding romance.
- 7. Saints Jan 26, 2016
- A patient's life is in jeopardy when legal issues complicate an essential bone marrow transplant.
- 6. Bound Jan 19, 2016
- Airplane stowaways are brought to the hospital with significant injuries.
- 5. Malignant Jan 5, 2016
- Saving a member of Firehouse 51; a woman saved from a burning building leads to a bigger mystery.
- 4. Mistaken Dec 8, 2015
- The doctors treat those injured in a movie theater shooting; a teenager with an eating disorder.
- 3. Fallback Dec 1, 2015
- Dr. Connor Rhodes is reunited with his sister as he treats a family friend.
- 2. iNO Nov 24, 2015
- Ethan treats a troubled teenager who's just given birth; Dr. Halstead treats a hypochondriac.
- 1. Derailed Nov 17, 2015
- An influx of train crash victims interrupts the grand opening of the emergency department.