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- Season 4 overviewSep 26, 2018-May 22, 201922 episodesSeason 4 episodes22. With a Brave Heart May 22, 2019
- Dr. Charles and Caroline set some major plans; Ava fights to keep her relationship with Connor.
- 21. Forever Hold Your Peace May 15, 2019
- Caroline shares news, forcing Dr. Charles to make a decision; Maggie meets her sister's boyfriend.
- 20. More Harm Than Good May 8, 2019
- Dr. Charles and Dr. Manning disagree on how to handle a patient who is poisoning herself.
- 19. Never Let You Go Apr 24, 2019
- The hospital goes into lockdown mode when a man with a gun holds medical staff hostage.
- 18. Tell Me the Truth Apr 3, 2019
- An alarming phone call prompts Rhodes to rush out of an important surgery.
- 17. The Space Between Us Mar 27, 2019
- A car smashes through the ambulance bay doors and Dr. Choi makes some difficult decisions.
- 16. Old Flames, New Sparks Feb 27, 2019
- Halstead treats a woman on the verge of freezing to death; Manning makes a house call.
- 15. We Hold These Truths Feb 20, 2019
- After a pickup truck plows through a street fair, Natalie and Maggie must make tough decisions.
- 14. Can't Unring That Bell Feb 13, 2019
- Connor handles a gunshot victim who has ties to Halstead; Charles has an awkward first date.
- 13. Ghosts in the Attic Feb 6, 2019
- Halstead hides the theft of his gun from Manning; Hank breaks down over a patient from his past.
- 12. The Things We Do Jan 23, 2019
- Manning and her 3-year-old patient are trapped in a helicopter as the toddler's stats decline.
- 11. Who Can You Trust Jan 16, 2019
- Halstead takes heat for making an unauthorized move to treat his pregnant patient.
- 10. All the Lonely People Jan 9, 2019
- A shooting outside the hospital injures April and leaves the ED shaken up.
- 9. Death Do Us Part Dec 5, 2018
- Halstead and Manning's wedding day is interrupted when Halstead is forced to make a house call.
- 8. Play by My Rules Nov 14, 2018
- Choi and Charles use trickery to help a patient with an itch she can't help but scratch.
- 7. The Poison Inside Us Nov 7, 2018
- After a chemical spill, the ED goes on lockdown, leaving one of Med's own hanging in the balance.
- 6. Lesser of Two Evils Oct 31, 2018
- Manning and Halstead must act fast to save the life of a physically abused wife.
- 5. What You Don't Know Oct 24, 2018
- Halstead's first task as a criminal informant puts a strain on his relationship with Manning.
- 4. Backed Against the Wall Oct 17, 2018
- Halstead is backed into a corner after unknowingly making a deal with a gangster.
- 3. Heavy Is the Head Oct 10, 2018
- Choi and the staff must help a kidnapped child who needs a kidney transplant.
- 2. When to Let Go Oct 3, 2018
- Chicago Med, Fire and P.D. cross paths when a high-rise fire floods Med with victims.
- 1. Be My Better Half Sep 26, 2018
- Halstead questions Manning's feelings about their upcoming wedding.