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- Season 5 overviewSep 27, 2021-May 16, 202218 episodesSeason 5 episodes1. New Beginnings Sep 27, 2021
- Shaun and Lea's upcoming engagement party has everyone in a festive mood.
- 2. Piece of Cake Oct 4, 2021
- The hospital takes on some unexpected changes that the staff is not prepared for.
- 3. Measure of Intelligence Oct 11, 2021
- Shaun confronts Salen about the many changes she has implemented since coming on at St. Bonaventure.
- 4. Rationality Oct 25, 2021
- The team treats a young girl whose father's personal research complicates their treatment plans.
- 5. Crazytown Nov 1, 2021
- Lea goes behind Shaun's back to help raise his negative patient satisfaction scores.
- 6. One Heart Nov 15, 2021
- Dr. Shaun Murphy and Dr. Alex Park must grapple with a life-and-death decision.
- 7. Expired Nov 22, 2021
- Shaun and Lea happen upon a car accident and discover a pregnant mother who has been badly injured.
- 8. Rebellion Feb 28, 2022
- Shaun is forced to confront Lea; Lim hopes to expose Salen's cover-up over an infant's death.
- 9. Yippee Ki-Yay Mar 7, 2022
- Andrews assigns Shaun and Allen to help perform a risky surgery to restore the voice of a pop star.
- 10. Cheat Day Mar 14, 2022
- The team treats a liver transplant patient whose organ donor unwittingly gave him cancer.
- 11. The Family Mar 21, 2022
- Shaun makes a personal connection with a precocious young patient, threatening his objectivity.
- 12. Dry Spell Mar 28, 2022
- While treating a woman with Valley fever, the doctors discover a secret she has been hiding.
- 13. Growing Pains Apr 4, 2022
- Helping a teenage biohacker whose self-experiments begin to compromise his health.
- 14. Potluck Apr 11, 2022
- Someone mistakenly brings a hallucinogen-laced dish to the hospital's company potluck.
- 15. My Way Apr 18, 2022
- Doctor Andrews treats a foster kid for injuries; Shaun and team look to Lea for help.
- 16. The Shaun Show May 2, 2022
- A documentary filmmaker follows Shaun and Lea's lives to showcase relationships of atypical couples.
- 17. The Lea Show May 9, 2022
- Sophie takes Lea out for a day of wedding planning; nurse Villanueva acts unprofessionally.
- 18. Sons May 16, 2022
- Shaun and Lea make a big life decision and are pleasantly surprised by the support they receive.