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  2. Isabella of Portugal (Isabel in Portuguese and Spanish) (1428 – 15 August 1496) was Queen of Castile and León as the second wife of King John II. She was the mother of Queen Isabella I of Castile.

  3. Isabella of Castile (April 22, 1451 – November 26, 1504) was queen of Castile and Aragon. Together with her husband, Ferdinand II of Aragon, their reign was a turning point for the Iberian Peninsula. The marriage of Isabella and Ferdinand joined the kingdoms of Castile and Aragon.

  4. Feb 1, 2019 · Updated on February 01, 2019. Isabella of Portugal Facts. Known for: regent of Spain during long absences of her husband, Charles V, Holy Roman Emperor. Titles: Empress, Holy Roman Empire; Queen of Germany, Spain, Naples, and Sicily; Duchess of Burgundy; princess (Infanta) of Portugal. Dates: October 24, 1503 - May 1, 1539. Background, Family:

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