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1. www.nature.com › articles › nprotGenome engineering using the CRISPR-Cas9 system | Nature ...

   www.nature.com › articles › nprot

   Oct 24, 2013 · The RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short palindromic repeats (CRISPR) adaptive immune system can be used to facilitate efficient genome engineering in...

   • Author: F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, Vineeta Agarwala, David A Scott, Feng Zhan...

   • Publish Year: 2013

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3. mcgovern.mit.edu › profile › feng-zhangFeng Zhang - MIT McGovern Institute

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   Zhang pioneered the development of CRISPR-Cas9 as a genome editing tool and its use in eukaryotic cells –including human cells – from a natural adaptive immune system found in bacteria. He has substantially expanded this toolbox through discovery and harnessing of new CRISPR and CRISPR-associated systems.

4. en.wikipedia.org › wiki › Feng_ZhangFeng Zhang - Wikipedia

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   Zhang, Doudna, and other colleagues from Harvard founded Editas Medicine in September 2013 to develop and commercialize CRISPR-based therapies. Zhang discovered Cas13 with Harvard colleague Eugene Koonin using computational biology methods. In 2016, Zhang cofounded Arbor Biotechnologies to develop Cas13 for therapeutic use.

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     Tinkering with Nature’s Tools: The CRISPR Pioneer Feng Zhang

     Nov 15, 2022

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     CRISPR Wizard Feng Zhang: The Making Of A Sunny Science Superstar

     Jul 21, 2021

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     Scientist Stories: Feng Zhang, Inventing CRISPR & Optogenetics

     Jun 3, 2023

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6. scholar.google.com › citations‪Feng Zhang‬ - ‪Google Scholar‬

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   Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity FA Ran, PD Hsu, CY Lin, JS Gootenberg, S Konermann, AE Trevino, ... Cell 154 (6), 1380-1389 , 2013

7. www.broadinstitute.org › bios › feng-zhangFeng Zhang | Broad Institute

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   Zhang is a molecular biologist developing and applying novel molecular technologies for studying the brain. Zhang pioneered the development of genome editing tools for use in eukaryotic cells – including human cells – from natural microbial CRISPR-Cas9 systems.

8. news.mit.edu › 2023 › fanzor-system-in-animals-canResearchers uncover a new CRISPR-like system in animals that ...

   news.mit.edu › 2023 › fanzor-system-in-animals-can

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   Jun 28, 2023 · A team of researchers led by Feng Zhang at the McGovern Institute for Brain Research at MIT and the Broad Institute of MIT and Harvard has uncovered the first programmable RNA-guided system in eukaryotes — organisms that include fungi, plants, and animals.

9. People also ask

   Could a CRISPR-based genome editing system be a new technology?

   • Like CRISPR-based systems, the Fanzor system can be easily reprogrammed to target specific genome sites, and Zhang said it could one day be developed into a powerful new genome editing technology for research and therapeutic applications.

   Researchers uncover a new CRISPR-like system in animals that can edit

   news.mit.edu/2023/fanzor-system-in-animals-can-edit-human-genome-0628

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   Is CRISPR RNA-guided?

   • Qi, L.S. et al. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 152, 1173–1183 (2013). Chang, N. et al. Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos. Cell Res. 23, 465–472 (2013). Gratz, S.J. et al. Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease.

   Genome engineering using the CRISPR-Cas9 system - Nature

   www.nature.com/articles/nprot.2013.143

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   Can CRISPR-Cas be multiplexed to facilitate high-efficiency genome editing?

   • CRISPR-Cas can be easily multiplexed to facilitate high-efficiency genome editing in mammalian cells: by using two sgRNAs, we were able to demonstrate simultaneous targeting of the human DYRK1A and GRIN2B loci at efficiencies of 65–68% for each locus in HEK 293FT cells ( Fig. 5b ).

   Genome engineering using the CRISPR-Cas9 system - Nature

   www.nature.com/articles/nprot.2013.143

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   What does Feng Zhang do?

   • Feng Zhang develops tools that are broadly applicable to studying genetic diseases and developing diagnostics and therapeutics. These molecular engineering tools are useful for understanding nervous system function and diseases with genetic links such as autism spectrum disorder.

   Feng Zhang - MIT McGovern Institute

   mcgovern.mit.edu/profile/feng-zhang/

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   What does the Zhang lab do?

   • A major aim of the Zhang lab is to develop genetic medicines using systems that can modulate human cells by targeting specific genes and processes. “A number of years ago, we started to ask, ‘What is there beyond CRISPR, and are there other RNA-programmable systems out there in nature?’” says Zhang.

   Researchers uncover a new CRISPR-like system in animals that can edit

   news.mit.edu/2023/fanzor-system-in-animals-can-edit-human-genome-0628

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   How has CRISPR-Cas9 changed the world?

   • On Oct 5, 2012, Zhang submitted a breakthrough paper which reported the first successful programmable genome editing and also the first successful use in mammalian cells of CRISPR-Cas9 (Cong et al. Science 2013). Zhang’s CRISPR technology afforded a method for mammalian genome editing and has had enormous impact on experimental science.

   Feng Zhang - MIT McGovern Institute

   mcgovern.mit.edu/profile/feng-zhang/

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10. be.mit.edu › directory › feng-zhangFeng Zhang, PhD | MIT Department of Biological Engineering

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    Dr. Zhang is a molecular biologist focused on improving human health. He played an integral role in the development of two revolutionary technologies, optogenetics and CRISPR-Cas systems, including pioneering the use of Cas9 for genome editing and discovering CRISPR-Cas12 and Cas13 systems and developing them for therapeutic and diagnostic ...