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  1. Dec 18, 2023 · Scleroderma is a condition in which skin symptoms arise from sclerosis, an autoimmune disease that sometimes affects internal organs. Look through pictures here.

  2. Feb 8, 2023 · Limited cutaneous systemic scleroderma was once known as CREST syndrome. The word “CREST” stands for: calcinosis; Raynaud’s phenomenon; esophageal dysmotility; sclerodactyly; telangiectasia

  3. Sep 29, 2023 · Systemic sclerosis can also cause symptoms in other organs and tissue, like your: Muscles: Numbness and swelling, especially in your hands and feet (your extremities). Joints: Stiffness, swelling and loss of mobility (how easily you can move your joint). Lungs: Coughing and shortness of breath ( dyspnea ).

  4. Jun 20, 2022 · CREST syndrome is a milder form of systemic scleroderma that typically only affects the hands, feet, lower arms, lower legs, and face. In some cases, it can also affect the lungs and digestive system. Symptoms of systemic scleroderma tend to appear between the ages of 30 and 50.

  5. Aug 29, 2020 · CREST. • CREST syndrome, also known as limited or localized scleroderma, is a diffuse connective tissue disease which is differentiated by changes in the skin and subcutaneous tissue, blood vessels, skeletal muscles, and internal organs. Biopsy of the skin reveals dermal fibrosis like the changes seen in the thickened skin of Systemic Sclerosis.

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