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  1. Dec 21, 2022 · Vitamin D deficiency has been involved in the pathogenesis of small-fiber neuropathy, particularly affecting nociceptor fibers , but also parasympathetic fibers, especially in younger patients affected by type 2 diabetes .

    • Table 2

      Vitamin D for the treatment of painful diabetic neuropathy ....

    • PMC Free Article

      Vitamin D levels are affected by ultraviolet exposure but it...

  2. Jan 16, 2020 · This randomized, placebo-controlled study examined the effect of vitamin D replacement therapy on neuropathic symptoms and balance in patients with diabetic neuropathic pain and low vitamin D levels.

    • Aylin Sari, Zeynep Akdoğan Altun, Cigdem Arifoglu Karaman, Basak Bilir Kaya, Bekir Durmus
    • 10.2147/JPR.S203176
    • 2020
    • J Pain Res. 2020; 13: 171-179.
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    • Overview
    • Symptoms
    • Causes
    • Risk Factors
    • Complications
    • Prevention

    Peripheral neuropathy happens when the nerves that are located outside of the brain and spinal cord (peripheral nerves) are damaged. This condition often causes weakness, numbness and pain, usually in the hands and feet. It also can affect other areas and body functions including digestion and urination. The peripheral nervous system sends informat...

    Every nerve in the peripheral system has a specific job. Symptoms depend on the type of nerves affected. Nerves are divided into: 1. Sensory nerves that receive sensation, such as temperature, pain, vibration or touch, from the skin. 2. Motor nerves that control muscle movement. 3. Autonomic nerves that control functions such as blood pressure, swe...

    Peripheral neuropathy is nerve damage caused by several different conditions. Health conditions that can cause peripheral neuropathy include: 1. Autoimmune diseases.These include Sjogren's syndrome, lupus, rheumatoid arthritis, Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy and vasculitis. Also, some cancers related to t...

    Peripheral neuropathy risk factors include: 1. Diabetes, especially if your sugar levels are not controlled well. 2. Alcohol misuse. 3. Low levels of vitamins in the body, especially vitamin B-12. 4. Infections, such as Lyme disease, shingles, hepatitis B and C, and HIV. 5. Autoimmune diseases, such as rheumatoid arthritis and lupus, in which the i...

    Complications of peripheral neuropathy can include: 1. Burns, skin injuries and wounds on the feet.You might not feel temperature changes or pain on parts of your body that are numb. 2. Infection.Your feet and other areas that lack sensation can become injured without your knowing. Check these areas regularly, wear close-toed, well-fitting shoes an...

    Manage underlying conditions

    The best way to prevent peripheral neuropathy is to manage medical conditions that put you at risk.

    Make healthy lifestyle choices

    These habits support your nerve health: 1. Eat a diet rich in fruits, vegetables, whole grains and lean protein to keep nerves healthy.Protect against low levels of vitamin B-12 by eating meats, fish, eggs, low-fat dairy foods and fortified cereals. If you're vegetarian or vegan, fortified cereals are a good source of vitamin B-12, but talk to your health care professional about B-12 supplements. 2. Exercise regularly.With a health care professional's OK, try to get at least 30 minutes to one...

  4. Mar 10, 2021 · Results: The prevalence of severe vitamin D deficiency (<10 ng/mL) was more common in the painful DPN group than in the painless DPN and no-DPN groups (25.8,12.5, and 8.1%, respectively, P < 0.01). Cases in the painful DPN group had significantly higher concentrations of IL-6 ( P < 0.01) and TNF-α ( P < 0.01) than those in the two other groups.

    • Gong Xiaohua, Luo Dongdong, Niu Xiaoting, Chen Shuoping, Shen Feixia, Yang Huajun, Zhou Qi, Chen Zim...
    • 10.3389/fnut.2021.612068
    • 2021
    • Front Nutr. 2021; 8: 612068.
  5. Previous studies have proved that there is an apparent vitamin D deficiency in PDN patients, and vitamin D supplementation can effectively improve patients’ pain symptoms and neurologic function. However, the evidence of these studies is unconvincing.

  6. Mar 22, 2024 · Vitamin D deficiency may affect large nerve fibers in patients with diabetes and peripheral neuropathy.

  7. Apr 12, 2022 · Neuropathy is one of the most important complications of diabetes. According to recent advances, vitamin D deficiency might play a role in the development and progression of diabetic neuropathy. Moreover, therapeutic vitamin D supplementation has the potential to improve this condition.

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