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- Babesiosis is usually diagnosed by finding Babesia in blood smears, but differentiation from Plasmodium species can be difficult. Tetrad forms (the so-called Maltese cross formation), although not common, are unique to Babesia and helpful diagnostically. Serologic and polymerase chain reaction (PCR)–based tests are available.
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What features on a blood smear suggest babesiosis and Plasmodium?
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Jul 31, 2023 · Objectives: Summarize the epidemiology of babesiosis. Review the sporozoite and merozoite forms of babesia as well as their role in the pathophysiology of babesiosis. Identify the characteristic Maltese cross in the peripheral blood smear of those with babesiosis.
- Andrea J. Zimmer, Kari A. Simonsen
- 2023/07/31
Babesia infection ranges from subclinical to severe, presenting with flu-like symptoms and clinical or laboratory signs of red blood cell destruction. Diagnosis requires careful examination, often including a detailed review of a peripheral blood smear to spot the parasite, especially in immunosuppressed patients.
Feb 13, 2024 · Immunocompromised patients require close clinical and laboratory follow up. Peripheral blood smears should be obtained daily until parasitemia is <4%, with smears done at least weekly after that. Treatment should be continued until parasites are no longer detected on smears for 2 consecutive weeks.
Nov 30, 2020 · This guideline covers the diagnosis and management of babesiosis, a tick-borne infection caused by intraerythrocytic protozoa. It does not mention blood smear as a diagnostic tool for babesiosis.
Sep 28, 2023 · Babesiosis is an infectious disease caused by protozoa of the genus Babesia that infect and lyse red blood cells. Babesia spp are transmitted primarily by tick vectors after their acquisition from small mammal reservoir hosts. Transmission occasionally occurs through blood transfusion and rarely through organ transplantation or congenitally.
Feb 15, 2017 · Babesia parasites can be visualized on blood smears using the Giemsa-Wright stain. They are intraerythrocytic ring forms that resemble plasmodium, the causative agent of malaria. There are a couple of distinguishing features that can hint towards one organism over the other on light microscopy .
Feb 15, 2017 · Blood smear revealed intraerythrocytic Babesia, which was confirmed by PCR. Bone marrow biopsy was remarkable for dyserythropoiesis, suggesting possible HLH, supported by other blood workup meeting HLH-2004 trial criteria. Conclusion.
