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  1. Apr 24, 2019 · Share: A prominent pediatrician and medical researcher in the Philippines has been indicted over the failedand many say premature—introduction of Dengvaxia, a vaccine against dengue that was yanked from the Philippine market in 2017 because of safety issues.

  2. Feb 6, 2018 · What went wrong with the breakthrough dengue vaccine? How a perfect storm of politics, panic and public health misinformation may have once again derailed a vaccine that can save lives. Karen Frances Eng. ·. Follow. Published in. TED Fellows. ·. 7 min read. ·. Feb 6, 2018. 9.

    • Karen Frances Eng
  3. Jun 23, 2021 · Scientists Discover How Dengue Vaccine Fails to Protect Against Disease. UNC School of Medicine scientists led by Aravinda de Silva, PhD, identified the small subpopulation of antibodies in vaccinated children that correlate with protection against dengue fever.

    • A Baffling Disease
    • A Red Flag
    • Ongoing Controversy
    • Toward A Safer Vaccine
    • Loss of Trust

    For most viruses, such as measles, the second bout, if it occurs at all, is much milder than the first. For dengue, a second bout is far more likely to kill. Scientists and doctors have struggled for years to understand why this is so. In the 1950s and 1960s, when epidemics of severe dengue began to rise in Asia, they wondered if they were dealing ...

    Coincidentally, days after Harris’s paper was published in November 2017, Sanofi Pasteur made the announcement that enraged Filipino parents: do not get Dengvaxia if you have not had dengue. A month later the WHO followed suit, stating that only individuals who were proved to already have had dengue should be given the vaccine. That was exactly wha...

    In July 2018 Sanofi Pasteur published its reanalysis of clinical trial data using the Pittsburgh test in the New England Journal of Medicine. The review confirmed a higher risk of severe disease and hospitalization in “seronegative” children (those who had no evidence of prior dengue infection in their blood) who had received the vaccine, compared ...

    With dengue infecting around a million people every day and popping up in places it has never been seen before, the need for a safe vaccine is becoming ever more urgent. Armed with the new information from Sanofi Pasteur, novel dengue vaccine makers are quick to say they are doing things differently. “We’ve designed our trial in such a way to ask t...

    The repercussions from the vaccination program are still reverberating across the Philippines. Speaking before a senate inquiry panel, Aquino explained that dengue incidence in the country had been increasing at an alarming rate, and he had hoped that Dengvaxia could prevent the virus from invading densely populated urban areas. By this past Februa...

  4. Jan 19, 2022 · Who Should Get a Dengue Vaccine? Where does Dengue Commonly Occur? Who Should Not Get a Dengue Vaccine? What Type of Dengue Vaccine Is Available? How Well Do These Vaccines Work? What Are the Possible Side Effects of the Dengue Vaccine? Where Can I Find This Vaccine? How Can I Get Help Paying for This Vaccine?

  5. Apr 15, 2023 · Abstract. Dengue is a major global public health problem requiring a safe and efficacious vaccine as the foundation of a comprehensive countermeasure strategy. Despite decades of attempts, the...

  6. Jan 31, 2024 · In 2019, the four serotypes of the mosquito-borne dengue virus (DENV) caused an estimated 56 million cases of disease and 5000 to 40,000 deaths in a global swath of tropical and near-tropical...

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