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  2. Should You Consider Paxlovid? Learn About The COVID Treatment & Other Treatment Options. This COVID Treatment That Can Help Reduce The Severity Of Symptoms & Speed Up Recovery.

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    • kathy.katella-cofrancesco@yale.edu
    • How does Paxlovid work? Paxlovid is an antiviral therapy that consists of two separate medications packaged together. When you take your three-pill dose, two of those pills will be nirmatrelvir, which inhibits a key enzyme that the COVID virus requires in order to make functional virus particles.
    • When should I take Paxlovid? You have to take Paxlovid within five days of developing symptoms. Like all antivirals, Paxlovid works best early in the course of an illness—in this case, within the first five days of symptom onset, says Jeffrey Topal, MD, a Yale Medicine infectious diseases specialist who is involved in determining COVID-19 treatment protocols for Yale New Haven Hospital patients.
    • How often do I take Paxlovid? The standard dose is three Paxlovid pills twice daily for five days for a full course that adds up to 30 pills. It helps that the pills are packaged in a “dose card,” basically a medication blister pack that allows you to punch out the pills as needed.
    • Is Paxlovid similar to Tamiflu? “I think it's a good comparison,” says Dr. Roberts. Tamiflu is an antiviral drug that reduces flu symptoms. Both are prescription-only oral antiviral pills given early in illness.
  1. Jan 10, 2023 · The antiviral treatment Paxlovid reduced the risk of hospitalization or death from SARS-CoV-2 Omicron variants in older adults by 44%. Wider use of Paxlovid may help temper a winter surge of COVID-19, as some other treatments are no longer effective.

    • What You Need to Know
    • What Did The Researchers do?
    • What Did They Learn?
    • Why Is This Research Important?
    • Where Can I Go to Learn More?
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    Antiviral drugs can lower the risk of severe illness and death from viral infections. In 2021, a clinical trial showed that Paxlovid — an antiviral treatment known generically as nirmatrelvir and ritonavir — reduces the risk of severe COVID-19. Since then, the antiviral treatment has been administered more than 7.6 million times and is available by...

    Researchers at Brigham and Women’s Hospital examined medical records from patients age 50 and older who had received a COVID-19 diagnosis in the first six months of 2022 (when Omicron variants were dominant). The records came from the Mass General Brigham health care system, which serves 1.5 million patients per year in Massachusetts and New Hampsh...

    The researchers found that people who had received Paxlovid had a 44% reduced risk of hospitalization or death from COVID-19 compared with those who did not receive the treatment. For people who had not been vaccinated, the risk of hospitalization or death was 81% lower if they took the antiviral drug. The researchers found that people who identifi...

    Paxlovid is an effective antiviral drug that reduces the risk of hospitalization and death against COVID-19, including cases caused by the Omicron variant. If you get COVID-19 and are at higher risk for severe disease, talk to your doctor about whether the treatment is appropriate for you.

    Paxlovid reduces serious risks from Omicron variants 1. Wider use of Paxlovid may help temper a winter surge of COVID-19, as some other treatments are no longer effective. Researchers Discover Potential New Antiviral Against COVID-19 1. NMT5 coats the receptors of healthy cells and temporarily changes their shape, making it harder for SARS-CoV-2 to...

    Administration for Strategic Preparedness and Response. COVID-19 Therapeutics Thresholds, Orders, and Replenishment by Jurisdiction. https://aspr.hhs.gov/COVID-19/Therapeutics/Orders/Pages/default.aspx Dryden-Peterson, S., Kim, A., Kim, A. Y., Caniglia, E. C., Lennes, I. T., Patel, R., Gainer, L., Dutton, L., Donahue, E., Gandhi, R. T., Baden, L. R...

  2. Jan 26, 2022 · Collectively, our findings show that therapeutic options may be available to combat the omicron variant of SARS-CoV-2; however, some therapeutic monoclonal antibodies may not be effective...

  3. Jan 18, 2022 · Nirmatrelvir’s EC 50 – a measure of drug potency showing a concentration that is effective in producing 50% of the maximal response – was 16 nM for the Omicron variant, compared to 38 nM for the USA-WA1/2020 variant, reaffirming its robust in vitro antiviral activity.

  4. Dec 7, 2022 · These results suggest that remdesivir, molnupiravir, and nirmatrelvir are efficacious against both BQ.1.1 and XBB in vitro. Our data suggest that the omicron sublineages BQ.1.1 and XBB have...

  5. May 13, 2022 · How effective is Paxlovid? Paxlovid has been found to be about 88% effective in preventing hospitalization and death in unvaccinated, high-risk adults with COVID-19.

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