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  2. May 15, 2024 · Laboratory testing. CDC recommends the use of FDA-cleared antibody tests for laboratory diagnosis of Lyme disease. As with antibody tests for other infectious diseases, the accuracy of these tests depends upon how long you've been infected.

    • The First Test: Elisa
    • The Second Test: Western Blot Or A Second Elisa
    • A Possible Drawback of The Two-Step Testing System

    This blood test is for antibodies against the Lyme disease bacteria. Because it can take some time for your body to produce antibodies, this test isn’t always accurate soon after a person is infected.

    There are two options for the second test. One is called a Western blot, which looks at how your antibodies react to specific parts of the Lyme disease bacteria. The Western blot test has been part of the two-step testing system since 1994 and is more commonly used. The other option is to do a second ELISA test, which measures antibodies to a speci...

    The CDC testing guidelines recommend a second test only if the first test is positive or unclear. Because the first test may not pick up antibodies soon after possible exposure to the Lyme disease bacteria, that means a person with Lyme disease may never get the second test. So, if your ELISA test is negative, you may want to ask your doctor to rep...

  3. Lyme testing isn't always accurate. If you receive a negative test, you still may have Lyme disease.

  4. Jun 30, 2023 · Arthritis. Reference. How Do I Know If I Have Lyme Disease? Medically Reviewed by David Zelman, MD on June 30, 2023. Written by WebMD Editorial Contributors. What Is Lyme Disease? How Is It...

  5. Jan 8, 2024 · Notably, the accuracy of these tests varies based on disease progression; what works during an earlier stage may not be as effective down the line, and vice versa. Here’s a quick breakdown: Early stage : Within a month of exposure to Lyme disease, during its “localized” phase, testing isn’t generally necessary if Lyme-specific symptoms ...

  6. Dec 21, 2016 · The Accuracy of Diagnostic Tests for Lyme Disease in Humans, A Systematic Review and Meta-Analysis of North American Research - PMC. Journal List. PLoS One. PMC5176185. As a library, NLM provides access to scientific literature.

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