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A mast cell (also known as a mastocyte or a labrocyte[1]) is a resident cell of connective tissue that contains many granules rich in histamine and heparin. Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.
May 16, 2024 · Mast cells stand guard, ready to activate a quick response against invaders. They use surface proteins (receptors) that act like antennas to receive incoming immune signals. Other immune cells communicate which invaders to look out for, and sound an alarm if they find an intruder.
Apr 4, 2024 · Mastocytosis happens when mast cells that protect your body from allergens and bacteria mutate (change) and become abnormal cells that set up a continuous allergic response. Mastocytosis symptoms can be mild or severe.
Mast cells are long-lived tissue-resident cells with an important role in many inflammatory settings including host defence to parasitic infection and in allergic reactions.
May 1, 2023 · Mast cells are immune cells derived from the myeloid lineage. After arising in the bone marrow, progenitor cells circulate and become home to various tissues. Under the influence of stem cell factors locally produced by many cells in the tissue, the progenitor differentiates into a mature mast cell.
Feb 15, 2024 · In this article, we focus on one type of immune cell – the mast cell. We discuss what mast cells are, how they are generated, their function in the body and conditions related to them.
Jan 6, 2016 · Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings.
Aug 5, 2024 · Mast cell, tissue cell of the immune system of vertebrate animals. Mast cells mediate inflammatory responses such as hypersensitivity and allergic reactions. They are scattered throughout the connective tissues of the body, especially beneath the surface of the skin, near blood vessels and
Feb 28, 2023 · Mast cell activation syndrome (MCAS) is a disorder in which mast cells, a normal type of cell found in your immune system, release excessive amounts of histamines and other chemicals that lead to allergy-like symptoms in your body.
This Review summarizes recent data on human mast cells, discusses differences with murine mast cells, and describes new tools to study this increasingly meaningful cell type in humans.
