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How does nitroglycerin work?
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Jul 31, 2023 · Mechanism of Action. As with other nitrates used to treat anginal chest pain, nitroglycerin converts to nitric oxide (NO) in the body.
- 2023/07/31
Mechanism of action. Nitroglycerin is converted by mitochondrial aldehyde dehydrogenase in smooth muscle cells to nitric oxide (NO), a potent vasodilator.
DrugInteractionThe risk or severity of adverse effects ...Nitroglycerin may increase the ...The therapeutic efficacy of Nitroglycerin ...The therapeutic efficacy of Nitroglycerin ...Mechanism of action. Glyceryl trinitrate is a prodrug which must be denitrated, with the nitrite anion or a related species further reduced to produce the active metabolite nitric oxide (NO). Organic nitrates that undergo these two steps within the body are called nitrovasodilators, and the denitration and reduction occur via a variety of ...
Feb 17, 2020 · Nitroglycerin is a nitrate that forms nitric oxide and relaxes smooth muscle. It reduces preload, afterload, and improves coronary flow. Learn about its dosage forms, pharmacokinetics, and uses.
At low doses, nitroglycerin dilates veins more than arteries, thereby reducing preload (volume of blood in the heart after filling); this is thought to be its primary mechanism of action. By decreasing preload, the heart has less blood to pump, which decreases oxygen requirement since the heart does not have to work as hard.
Jul 9, 2022 · Nitroglycerin is converted to nitric oxide, a potent vasodilator, in the body, leading to venodilation at lower dosages and arteriodilation at higher dosages that results in both preload and afterload reduction, respectively.
Nov 7, 2017 · In this review, we detail the discovery of nitroglycerin and its early use in the treatment of angina; the history of the discovery of nitric oxide, its sources, and its roles; the mechanism of action, preparations, and hemodynamic and non-hemodynamic effects of the organic nitrates, as well as their biotransformation; and the clinical uses and ...
