Yahoo Web Search

Search results

1. People also ask

   What is NMDA receptor in Alzheimer's disease?

   • Keywords: NMDA receptor, amyloid beta, memantine, Alzheimer’s disease, synaptic dysfunction Alzheimer’s disease (AD) is an age-related neurodegenerative disease. Clinically, this disorder is characterized by global cognitive dysfunction, especially memory loss, behavior and personality changes.

   The Role of NMDA Receptors in Alzheimer’s Disease - PMC

   www.ncbi.nlm.nih.gov/pmc/articles/PMC6375899/

   See all results for this question

   Do doctors use NMDA receptor antagonists?

   • But doctors do use one NMDA receptor antagonist: memantine ( Namenda XR). It's been approved in the U.S. and Europe as a treatment for Alzheimer's disease. It's typically used when a person has more advanced symptoms and has shown modest benefits in patients with moderate to severe Alzheimer’s disease.

   NMDA Receptor Antagonists and Alzheimer's - WebMD

   www.webmd.com/alzheimers/nmda-receptor-antagonists

   See all results for this question

   Can NMDA help treat Alzheimer's disease?

   • NMDA (short for N-methyl-D-aspartate) receptor antagonists are a class of drugs that may help treat Alzheimer's disease, which causes memory loss, brain damage, and, eventually, death. There's no cure for Alzheimer's, but some drugs may slow it down. Your brain has billions of nerve cells called neurons.

   NMDA Receptor Antagonists and Alzheimer's - WebMD

   www.webmd.com/alzheimers/nmda-receptor-antagonists

   See all results for this question

   Is memantine an NMDA antagonist for Alzheimer's disease?

   • Accordingly, we investigated memantine, an NMDA antagonist, for the treatment of Alzheimer's disease. Patients with moderate-to-severe Alzheimer's disease were randomly assigned to receive placebo or 20 mg of memantine daily for 28 weeks.

   Memantine in Moderate-to-Severe Alzheimer's Disease | NEJM

   www.nejm.org/doi/full/10.1056/NEJMoa013128

   See all results for this question

2. www.webmd.com › alzheimers › nmda-receptor-antagonistsNMDA Receptor Antagonists and Alzheimer's - WebMD

   www.webmd.com › alzheimers › nmda-receptor-antagonists

   • Cached

   Sep 2, 2022 · NMDA (short for N-methyl-D-aspartate) receptor antagonists are a class of drugs that may help treat Alzheimer's disease, which causes memory loss, brain damage, and, eventually, death.

3. www.ncbi.nlm.nih.gov › pmc › articlesThe Role of NMDA Receptors in Alzheimer’s Disease - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 8, 2019 · Memantine, a non-competitive NMDA receptor antagonist, is approved for use in moderate to severe AD. It has been widely prescribed to provide symptomatic relief and enhance life quality in AD, even if it did not improve excessive agitation (Fox et al., 2012), and hippocampal or total brain atrophy (Wilkinson et al., 2012). However, in the brain ...

   • Author: Jinping Liu, Lirong Chang, Yizhi Song, Hui Li, Yan Wu

   • Publish Year: 2019

4. www.ncbi.nlm.nih.gov › books › NBK500025Memantine - StatPearls - NCBI Bookshelf - National Center for ...

   www.ncbi.nlm.nih.gov › books › NBK500025

   Jan 31, 2024 · Memantine is an uncompetitive antagonist of the NMDA subtype of glutamate receptors in the CNS. Alzheimer disease is believed to be caused by overstimulation of glutamate, the primary excitatory amino acid in the CNS, resulting in excitotoxicity and neuronal degeneration.

   • Published: 2024/01/31

5. www.ncbi.nlm.nih.gov › pmc › articlesN-Methyl D-Aspartate (NMDA) Receptor Antagonists and ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Memantine, a partial antagonist of N-methyl-D-aspartate receptor (NMDAR), approved for moderate to severe Alzheimer’s disease (AD) treatment within the US and Europe under brand name Namenda (Forest), Axura and Akatinol (Merz), and Ebixa and Abixa (Lundbeck), may have potential in alleviating additional neurological conditions, such as ...

   • Author: David Olivares, Varun K. Deshpande, Ying Shi, Debomoy K. Lahiri, Nigel H. Greig, Jack T. Rogers, Xud...
   • DOI: 10.2174/156720512801322564

   • Publish Year: 2012
   • Published: 2012/07

6. www.frontiersin.org › journals › neuroscienceFrontiers | The Role of NMDA Receptors in Alzheimer’s Disease

   www.frontiersin.org › journals › neuroscience

   • Cached

   Central role for NMDA receptors in redox mediated impairment of synaptic function during aging and Alzheimer’s disease. Behav. Brain Res. 322, 223–232. doi: 10.1016/j.bbr.2016.05.012

7. Images

   • 
   • 
   • 
   • 
   • 

   View all

8. www.nejm.org › doi › fullMemantine in Moderate-to-Severe Alzheimer's Disease | New ...

   www.nejm.org › doi › full

   Apr 3, 2003 · Memantine, an uncompetitive NMDA-receptor antagonist, could be of therapeutic value in Alzheimer's disease. 12 A recent study in patients with advanced dementia (Alzheimer's disease and...

9. www.nature.com › articles › s41386/023/01614-3Therapeutic potential of N-methyl-D-aspartate receptor ...

   www.nature.com › articles › s41386/023/01614-3

   Jun 27, 2023 · NMDA receptor modulators have long been considered as potential treatments for psychiatric disorders including depression and schizophrenia, neurodevelopmental disorders such as Rett Syndrome,...