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Osteomyelitis after trauma is increasing. Biofilm is the hallmark of chronic infection that makes osteomyelitis a surgical disease. Thorough workup and staging of the bone and the host using the Cierny-Mader Classification is crucial to developing an effective treatment plan.
- 5MB
- 83
- 1. Introduction
- 1.3 Osteomyelitis secondary to contiguous infection
- 2. Host factors
- 3. Pathogen factors
- Published in print edition March, 2012
The term osteomyelitis encompasses a broad group of infectious diseases characterized by infection of the bone and/or bone marrow. The pathogenesis of these diseases can follow acute, subacute or chronic courses and involves a range of contributory host and pathogen factors. A commonly used aetiological classification distinguishes between three ty...
In adult patients, the majority of osteomyelitis cases are due to inoculation from contiguous infection. Sources can include direct contamination at a site of injury, iatrogenic contamination at the time of an invasive procedure, or invasive infection from surrounding soft tissue. The epidemiology of contiguous infection osteomyelitis is biphasic, ...
The pathogenesis of osteomyelitis is a complex process involving interactions between a host and an infectious agent. The host’s inflammatory response to a pathogen can further the physical spread of disease by clearing space in bone. Predisposing genetic differences in immune function are increasingly seen as an aetiological factor in some cases o...
The initial event in the localization of infection appears to be adhesion of the bacteria to the extracellular matrix (ECM). Various factors govern this adhesion process. Once a bacteria reaches the biomaterial surface by haematogenous route they acquire a conditioning film of ECM proteins. Osteoblast play an active role in the internalization of t...
If you want to learn more about osteomyelitis you should not miss this book. The editors are professionals and scientists working in health sciences and the chapters have been prepared by experts in the field, covering subjects related with the fundamentals of osteomyelitis and new diagnosis and treatment tools. You will have the opportunity to rev...
- 615KB
- Mayank Roy, Jeremy S. Somerson, Kevin G. Kerr, Jonathan L. Conroy
- 26
- 2012
May 31, 2023 · Osteomyelitis is a serious infection of the bone that can be either acute or chronic. It is an inflammatory process involving the bone and its structures caused by pyogenic organisms that spread through the bloodstream, fractures, or surgery.
- Ifeanyi I. Momodu, Vipul Savaliya
- 2023/05/31
- Campbell University School of OM
In this review, we describe the pathophysiology of osteomyelitis and the currently used in vitro systems for osteomyelitis research, with the focus on the most recent discoveries and improved mechanistic understandings of the pathophysiology of osteomyelitis.
Oct 26, 2016 · This review article summarizes the recent advances in pathogenic mechanisms and novel therapeutic strategies for osteomyelitis, covering both periprosthetic joint infections and fracture-associated bone infections.
- Mitchell C. Birt, David W. Anderson, E. Bruce Toby, Jinxi Wang
- 10.1016/j.jor.2016.10.004
- 2017
- J Orthop. 2017 Mar; 14(1): 45-52.
Osteomyelitis is an inflammatory condition of bone secondary to an infectious process. Osteomyelitis is usually clinically diagnosed with support from imaging and laboratory findings.
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Mar 1, 2017 · Recent advances in experimental and clinical studies on osteomyelitis have significantly improved our understanding of pathophysiology of osteomyelitis, including the mechanisms of bacterial adherence, biofilm formation, intracellular infection, and bone destruction.
