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May 9, 2024 · Paxlovid rebound typically happens within a week after you've taken Paxlovid to treat COVID-19. With Paxlovid rebound, either your COVID-19 symptoms return or you test positive after testing negative.
May 26, 2022 · CDC on Tuesday issued a warning saying that patients who complete a five-day course of Paxlovid and experience a return of Covid-19 symptoms should isolate for an additional five days, marking the first guidance the agency has issued on what patients should do if they test positive for Covid-19 days after testing negative.
- kathy.katella-cofrancesco@yale.edu
- How does Paxlovid work? Paxlovid is an antiviral therapy that consists of two separate medications packaged together. When you take your three-pill dose, two of those pills will be nirmatrelvir, which inhibits a key enzyme that the COVID virus requires in order to make functional virus particles.
- When should I take Paxlovid? You have to take Paxlovid within five days of developing symptoms. Like all antivirals, Paxlovid works best early in the course of an illness—in this case, within the first five days of symptom onset, says Jeffrey Topal, MD, a Yale Medicine infectious diseases specialist who is involved in determining COVID-19 treatment protocols for Yale New Haven Hospital patients.
- How often do I take Paxlovid? The standard dose is three Paxlovid pills twice daily for five days for a full course that adds up to 30 pills. It helps that the pills are packaged in a “dose card,” basically a medication blister pack that allows you to punch out the pills as needed.
- Is Paxlovid similar to Tamiflu? “I think it's a good comparison,” says Dr. Roberts. Tamiflu is an antiviral drug that reduces flu symptoms. Both are prescription-only oral antiviral pills given early in illness.
- kathy.katella-cofrancesco@yale.edu
- What, exactly, is COVID rebound? COVID rebound is defined as a recurrence of COVID symptoms and/or receiving a positive COVID test after having the disease and then testing negative.
- What do you need to know about Paxlovid? The drug, available by prescription from health care providers and some pharmacists, is available to everyone ages 12 and older (weighing at least 88 pounds) who has mild-to-moderate disease and is at high risk for severe disease.
- Does Paxlovid cause COVID rebound? So far, researchers say there is no strong evidence of that. The CDC notes in a health advisory that “a brief return of symptoms may be part of the natural history of SARS-CoV-2 infection in some persons, independent of treatment with Paxlovid and regardless of vaccination status.”
- What causes COVID rebound? Scientists are still studying the phenomenon. In the meantime, researchers are focusing on the effects of longer treatment durations, longer isolation periods, and other ways of managing the problem, Dr. Roberts adds.
Feb 20, 2024 · “If you're testing positive following a previous negative test or following a full course of Paxlovid, that's where masking and distancing becomes important,” Pekosz says. “But again, only at the tail end of an infection, when you’re feeling better and symptoms aren’t severe.”
Nov 13, 2023 · A new study by Harvard Medical School researchers at Massachusetts General Hospital and Brigham and Women’s Hospital has found that one in five individuals taking nirmatrelvir-ritonavir therapy, commonly known as Paxlovid, to treat severe symptoms of COVID-19 had a positive test result and shed live potentially contagious virus following an ...
May 4, 2022 · If you don’t have any tests and don’t have access to a health care provider, a Test-to-Treat site can administer a COVID-19 test, and if that test is positive, prescribe a treatment on the spot. If you test negative but your symptoms persist, take another rapid test the next day or get a more sensitive PCR (polymerase chain reaction) test ...
