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  2. Jan 14, 2019 · With a population of 459,787 people, Kansas City is the largest city in Missouri. It is the country’s 37th biggest city. It was established as a port city on the Missouri River in the 1830s. It is located at the confluence of the Kansas and Missouri Rivers. Kansas City extends across several counties.

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  3. Jan 24, 2023 · Columbia - 131,579. Independence - 124,865. Lee's Summit - 104,030. O'Fallon - 94,913. Saint Charles - 71,903. St. Joseph - 71,180. Blue Springs - 60,412. 1. Kansas City - 522,580. Kansas City, Missouri. Kansas City has an estimated population of 522,580 and is the largest in the state in both population and area.

  4. Kansas City, Missouri (KC or KCMO) is the largest city in the U.S. state of Missouri by population and area. Most of the city lies within Jackson County , with portions spilling into Clay , Platte , and Cass counties.

  5. Jan 4, 2024 · What is the largest city in Missouri? The largest city in Missouri is Kansas City, with a population of 508,394. Kansas City is the 37th largest city in the US. The second largest city is St. Louis, with a population of 293,310, and is the 70th largest city in the US.

  6. The most populated cities in Missouri are Kansas City with 505,958, St. Louis at 298,018, Springfield with 168,873, Columbia at 126,172, and Independence with 122,218.

  7. Jan 4, 2024 · Top 100 Biggest Cities In Missouri (2019 Census) Rank. City. 2020 Pop ulation ( Est. ) Growth Rate (Ann ual ) 1. Kansas City. 495,327. 0.8%.

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