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May 8, 2024 · Progressive transformation of germinal centers (PTGC) is a clinicopathologic entity characterized by chronic lymphadenopathy with a wide age distribution.
Mar 1, 2018 · Progressive transformation of germinal centers (PTGC) is a common, but often underdiagnosed cause of benign peripheral lymphadenopathy that is characterized by reactive follicular hyperplasia along with mantle zone lymphocyte expansion into the adjacent sinusoids and germinal centers (GC); the follicles with GC become enlarged and replaced by ...
Progressive transformation of germinal centres ( PTGCs) is a reactive lymph node process of undetermined cause. Signs and symptoms. PTGC is usually characterized by localized lymphadenopathy and is otherwise typically asymptomatic. Diagnosis. Micrograph showing PTGCs. H&E stain.
Progressive transformation of germinal centers (PTGC) is a benign disorder of unknown etiology associated with follicular hyperplasia. It occurs predominantly in children and young males, but no age is exempt. Like NLPHL, PTGC tends to recur, especially in the same site.
This case series demonstrates the close histologic characteristics of progressive transformation of germinal centers and lymphocyte-predominant Hodgkin lymphoma. Prompt surgical excision of persistently enlarged lymph nodes and close monitoring for recurrence is recommended.
Mar 22, 2022 · Progressive Transformation of Germinal Centers. Progressive transformation of the germinal center (PTGC) is a common and underrecognized cause of pediatric lymphadenopathy. PTGC may be associated with numerous systemic medical conditions that require further workup and management, including malignancy, autoimmune conditions, lymphoproliferative c …
Mar 1, 2018 · Progressive transformation of germinal centers (PTGC) is a common, but often underdiagnosed cause of benign peripheral lymphadenopathy that is characterized by reactive follicular hyperplasia along with mantle zone lymphocyte expansion into the adjacent sinusoids and germinal centers (GC); the follicles with GC become enlarged and replaced by ...
