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  1. Apr 27, 2023 · Solitary fibrous tumors are growths of cells that can form in almost any part of the body. The growths, called tumors, start from cells in the tissues that support other tissues in the body, known as connective tissues. Solitary fibrous tumors are rare. They mainly affect older adults.

  2. Soft tissue - Solitary fibrous tumor (extrapleural); fibroblastic tumor characterized by haphazardly arranged spindled to ovoid cells, prominent staghorn vasculature and NAB2-STAT6 gene rearrangement

    • Overview
    • Symptoms and Causes
    • Diagnosis and Tests
    • Management and Treatment
    • Prevention
    • Outlook / Prognosis
    • Living With
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    A solitary fibrous tumor is a type of soft tissue tumor. These tumors can form anywhere in your body. Most are noncancerous, but in rare instances, the tumors can become cancerous and spread. Treatments include surgery, radiation therapy, chemotherapy and targeted therapy.

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    What causes solitary fibrous tumors?

    Experts aren’t sure why some people develop solitary fibrous tumors. Research suggests that two genes — NAB2 and STAT6 — may join or fuse together. This fused gene or gene change may increase your risk of developing a solitary fibrous tumor.

    What are the symptoms of a solitary fibrous tumor?

    Solitary fibrous tumors tend to grow slowly. Up to half of people with solitary fibrous tumors don’t have symptoms. Symptoms may only occur once the tumor gets large and presses on nearby organs, bones or tissues. When they occur, symptoms vary depending on which part of your body the tumor affects. Signs of a solitary fibrous tumor in your chest cavity, including the pleura and lungs, include: Chronic cough. Clubbed fingers and nails (enlarged fingertips and abnormal growth of nails). Noncardiac chest pain. Shortness of breath (dyspnea). Signs of a solitary fibrous tumor in the orbit of your eyes can affect your vision, causing: Bulging eyes (proptosis). Double vision (diplopia). Drooping eyelid (ptosis). Eye pain. Low vision. Swollen eyelids (blepharitis). Watery eyes. Signs of a solitary fibrous tumor in your sinuses or nasal cavity include: Bulging eyes. Drooping eyelids. Nasal congestion. Runny nose. Signs of a solitary fibrous tumor in your brain include: Delirium. Dizziness. Gait disorders. Headaches. Hearing loss. One-sided paralysis (hemiplegia). Signs of a solitary fibrous tumor in your spinal cord include: Back pain. Neck pain. Neuropathy or neuropathic (nerve) pain. Numbness. Shoulder pain. Urinary incontinence. Signs of a solitary fibrous tumor in your liver include: Bloated stomach. Discomfort or malaise (generally not feeling well). Fatigue. Signs of a solitary fibrous tumor in your thyroid include: Difficulty swallowing (dysphagia). Hoarseness. Lump or mass in your neck. Shortness of breath. Advertisement

    How do healthcare providers diagnose solitary fibrous tumors?

    Tests for solitary fibrous tumors depend on your symptoms and the tumor location. They may include: An eye exam, including optical coherence tomography (OCT) and visual field testing, to pinpoint the cause of vision problems. Imaging scans like X-rays, CT scans, MRIs, ultrasounds and PET scans to find tumors. A biopsy to determine the tumor type and whether it’s cancerous.

    How are solitary fibrous tumors treated?

    Healthcare providers perform surgery to remove a solitary fibrous tumor. If surgery isn’t an option, you may get radiation therapy to shrink and destroy it. Some people get radiation therapy prior to surgery to make the tumor smaller and easier to remove.

    What are the complications of solitary fibrous tumors?

    The development of cancer, especially cancer that spreads (metastatic cancer), is a major concern when you have a solitary fibrous tumor. Treatments like surgery can lower the risk of this complication. However, even with treatment, a solitary fibrous tumor can recur (come back). Tumors that recur are more likely to become cancerous and spread. Other complications depend on the tumor’s location. These complications may include: Paralysis. Pleural effusion, which affects your chest, lungs and pleura. Optic atrophy, damage to the optic nerves that carry messages from your eyes to your brain. Care at Cleveland Clinic Get Cancer Care for Adults Get Cancer Care for Children Make an Appointment

    Can you prevent solitary fibrous tumors?

    Because solitary fibrous tumors occur for no known reason, there isn’t anything you can do to prevent them.

    What’s the outlook for someone with a solitary fibrous tumor?

    Most people do well after surgical removal of the tumor. In rare instances, a tumor may come back after treatment and become cancerous. Your healthcare provider will order more frequent imaging scans to check for tumor recurrence.

    When should I call the doctor?

    You should call your healthcare provider if you experience: Chest pain. Difficulty breathing. Unexplained fatigue. Vision problems.

    What should I ask my provider?

    You may want to ask your healthcare provider: Where’s the tumor located? Is surgical removal an option? What are the signs of a tumor recurrence? How often should I get imaging scans? Should I look for signs of complications? A note from Cleveland Clinic It can be upsetting to find out that you have a tumor. Although rare, these tumors have the potential to turn into cancer and spread. Fortunately, your healthcare provider can surgically remove a solitary fibrous tumor to lower your cancer risk. Sometimes, a solitary fibrous tumor grows back. A recurring tumor is more likely to develop into cancer. You’ll get more frequent imaging scans to check for a tumor recurrence and protect your health. Medically Reviewed Last reviewed by a Cleveland Clinic medical professional on 02/23/2023. Learn more about our editorial process.

    Learn about solitary fibrous tumors, rare soft tissue growths that can form anywhere in your body. Find out how they are diagnosed, treated and prevented, and what are the risks and outlook.

  3. May 25, 2023 · A comprehensive overview of solitary fibrous tumor (SFT), a rare fibroblastic mesenchymal neoplasm that can arise in various sites, including the thorax and the central nervous system. Learn about the clinical features, diagnosis, management, and prognosis of SFT.

  4. Jun 10, 2021 · Solitary fibrous tumor (SFT) is a malignant condition that exhibits different clinical behaviors ranging from low to high aggressive SFT, with dedifferentiated SFT (DD-SFT) being the fastest-growing subtype.

    • Javier Martin-Broto, Jose L. Mondaza-Hernandez, David S. Moura, Nadia Hindi
    • 10.3390/cancers13122913
    • 2021
    • Cancers (Basel). 2021 Jun; 13(12): 2913.
  5. Solitary fibrous tumor (SFT), also known as fibrous tumor of the pleura, is a rare mesenchymal tumor originating in the pleura or at virtually any site in the soft tissue including the seminal vesicle. Approximately 78% to 88% of SFT's are benign and 12% to 22% are malignant.

  6. Jan 12, 2024 · Learn about solitary fibrous tumors, a rare neoplasm of mesenchymal origin that can occur in various locations and have different grades of malignancy. Find out the clinical presentation, pathology, genetics, radiographic features, treatment and prognosis of this condition.

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