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- It is now appreciated that complement is a complex network of plasma and membrane-associated serum proteins which can elicit highly efficient and tightly regulated inflammatory and cytolytic immune responses to infectious organisms (bacteria, viruses, parasites), tissue damaged by physical, chemical, or neoplastic insults, and other surfaces identified as 'nonself'.
The recognition of microbe- or danger-associated molecular patterns by complement proteins initiates a cascade of events that culminate in the engagement of complement receptors on the surface of immune cells.
- Table 1
Complement Receptor Ligand Cell Expression Function...
- Mannose-binding Lectin Deficiency Influences Innate and Antigen-Presenting Functions of Blood Myeloid Dendritic Cells
Mannose-binding lectin (MBL) is a serum lectin that plays a...
- Table 1
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Dec 15, 2009 · The role of complement in the immune system, and consequently on human health, has expanded dramatically. It is a well-characterized and an evolutionarily ancient component of host defense ...
- Jason R Dunkelberger, Wen-Chao Song
- 2010
Aug 7, 2019 · The complement system is a crucial mediator of the innate immune response, contributing to cell homeostasis, tissue development, and repair, reproduction, and cross-talk with other endogenous systems.
- Maciej Cedzyński, Nicole M. Thielens, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Thoma...
- 2019
Activated complement generates three major types of effectors: (1) anaphylatoxins (C3a and C5a), which are potent proinflammatory molecules that attract and activate leukocytes through interaction with their cognate G-protein–coupled receptors, C3a receptor (C3aR) and C5a receptor (C5aR); (2) opsonins (C3b, iC3b, and C3d), which decorate target ...
- Marina Noris, Giuseppe Remuzzi
- 10.1016/j.semnephrol.2013.08.001
- 2013
- Semin Nephrol. 2013 Nov; 33(6): 479-492.
Aug 19, 2010 · Research over the past decade has drawn a picture of how complement acts as an intricate immune surveillance system to discriminate among healthy host tissue, cellular debris, apoptotic cells...
- Daniel Ricklin, George Hajishengallis, Kun Yang, John D Lambris
- 2010
Aug 15, 2012 · Key Concepts: Complement is a multiprotein network of plasma proteins and cell surface receptors. Complement is an evolutionary conserved system. Complement participates in innate and adaptive immunity. Complement dysregulation and deficiencies are connected to disease.
This manuscript will provide a brief overview into the complex nature of the complement cascade, outlining some of their complement-independent functions, their effects at different locale, and their implication in disease settings.
