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Zhang pioneered the development of CRISPR-Cas9 as a genome editing tool and its use in eukaryotic cells –including human cells – from a natural adaptive immune system found in bacteria. He has substantially expanded this toolbox through discovery and harnessing of new CRISPR and CRISPR-associated systems.
- Research Areas - MIT McGovern Institute
Understanding how the brain gives rise to the mind...
- Researchers uncover a new CRISPR-like system in animals that ...
A team of researchers led by Feng Zhang at the McGovern...
- Research Areas - MIT McGovern Institute
His lab has also developed a sensitive diagnostic nucleic acid detection protocol that is based on CRISPR termed SHERLOCK (Specific High sensitivity Enzymatic Reporter UnLOCKing) that is able to detect and distinguish strains of viruses and bacteria present in as low as attomolar (10 −18 M) concentration. [19]
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity FA Ran, PD Hsu, CY Lin, JS Gootenberg, S Konermann, AE Trevino, ... Cell 154 (6), 1380-1389 , 2013
Oct 24, 2013 · The RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short palindromic repeats (CRISPR) adaptive immune system can be used to facilitate efficient genome engineering in...
- F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, Vineeta Agarwala, David A Scott, Feng Zhan...
- 2013
In this pursuit, he pioneered the development of CRISPR-Cas9 as a genome editing tool and its use in eukaryotic cells — including human cells — from a natural adaptive immune system found in bacteria. He has substantially expanded this toolbox through discovery and harnessing of new CRISPR and CRISPR-associated systems.
Dec 10, 2014 · This protocol from Feng Zhang's lab enables genome-scale knockout and transcriptional activation screening using the CRISPR-Cas9 system, as sgRNA libraries are constructed and packaged...
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Jun 28, 2023 · A team of researchers led by Feng Zhang at the McGovern Institute for Brain Research at MIT and the Broad Institute of MIT and Harvard has uncovered the first programmable RNA-guided system in eukaryotes — organisms that include fungi, plants, and animals.
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