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Immune Privilege. Immune privilege refers to the fact that foreign-tissue grafts placed in the immune-privileged site are tolerated and survive for prolonged, often indefinite, intervals, while placement of such grafts at conventional body sites leads to acute irreversible immune rejection. From: Retina (Fifth Edition), 2013
Jul 2, 2008 · Immune privilege is a concept that has come of age. Where previously it was considered to be a passive phenomenon restricted to certain specialized tissues, it is now viewed as comprising several ...
- John Vincent Forrester, Heping Xu, T. Lambe, R. J. Cornall
- 2008
Immune privilege is a concept that involves keeping adaptive immunity and inflammation highly controlled. The central nervous system (CNS) has been considered immune privileged since the 1920s when it was demonstrated that rat sarcoma transplanted into mouse brain parenchyma survived [5].
Sep 4, 2017 · The original concept of 'immune privilege' was coined to explain the failure of certain tissues to reject implanted grafts 1.Many tissues and organs are considered to be immune privileged — they ...
- Ilaria Spadoni, Giulia Fornasa, Maria Rescigno, Maria Rescigno
- 2017
Sep 21, 2012 · Immune privileged organs were operationally defined as sites in the body where foreign tissue grafts can survive for extended, often indefinite periods of time, whereas similar grafts placed at regular sites in the body are acutely rejected ( Medawar, 1948 ). These organs include the eye and the brain, as well as the pregnant uterus, testis ...
- Inbal Benhar, Anat London, Michal Schwartz
- 10.3389/fimmu.2012.00296
- 2012
- Front Immunol. 2012; 3: 296.
Sep 14, 2006 · The original notion of physical barriers that segregate immunogenic tissues from immune effector cells is no longer considered sufficient to explain an immune-privileged state, even when combined with the more modern notion of ‘passive ignorance’, in which segregated circulations prevent encounters that could activate antigen-specific T cells.
Immune privilege is a concept that has come of age. Where previously it was considered to be a passive phenomenon restricted to certain specialized tissues, it is now viewed as comprising several mechanisms, both active and passive, shared in many aspects with emerging notions of the mechanisms of p ….
