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In his most famous experiment, Loewi took fluid from one frog heart and applied it to another, slowing the second heart and showing that synaptic signaling used chemical messengers. The Nobel Prize diploma of Otto Loewi, housed at the University of Graz
In that famous experiment, Loewi placed two beating frog hearts, each in its own perfusion chamber – one preparation had the vagus nerve intact, while the other was denervated. Next, he stimulated the vagus nerve supplying the first heart, causing it to beat more slowly – a phenomenon that was already well known at the time.
- Alli N McCoy, Siang Yong Tan
- 10.11622/smedj.2014002
- 2014
- Singapore Med J. 2014 Jan; 55(1): 3-4.
May 27, 2021 · The paper reported an ingenious, yet straightforward experiment made by Professor Otto Loewi in 1920 and published in 1921, which constitutes the first clear-cut proof for the chemical nature of transmission of the nerve impulse from nerve to muscle.
- Ricardo Borges, Antonio G. García
- 2021
Back in 1921, an Austrian scientist named Otto Loewi discovered the first neurotransmitter. In his experiment (which came to him in a dream), he used two frog hearts. One heart (heart #1) was still connected to the vagus nerve. Heart #1 was placed in a chamber that was filled with saline.
Oct 1, 2018 · Otto Loewi (1873-1961) was a German pharmacologist. He is best known for his characterization of acetylcholine as the chemical substance that influences the rate of a heart beating in frogs, an experiment that was first published in 1921.
Acetylcholine was the first neurotransmitter discovered and chemically isolated, a feat which earned two researchers the shared Nobel Prize in Physiology or Medicine in 1936. One of the two scientists, a German pharmacologist named Otto Loewi, stimulated the vagus nerve connected to an isolated frog heart, which caused the heart rate to slow down.
In a simple but visionary experimental twist, Loewi placed a beating frog's heart, with its vagus nerve still attached, in a saline bath. The saline in the bath was allowed to flow into a second bath containing a second beating heart, this time with the vagus nerve removed.
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