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1. • • The worldwide spread of TB is mainly caused by the emergence of multidrug-resistant (MDR) M. tuberculosis strains, thus underlining the need for novel antimycobacterial drugs with improved efficacy. Research in TB chemotherapy, as well as in vaccine development, has entered an intense phase in an attempt to combat this disease.
     pubmed.ncbi.nlm.nih.gov › 11829709

     Re-emergence of tuberculosis: strategies and treatment

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   Is tuberculosis re-emergence a global emergency?

   • Re-emergence of tuberculosis: strategies and treatment Tuberculosis (TB) was declared a global emergency by the WHO in 1993. Approximately one third of the world's population is infected with Mycobacterium tuberculosis. Despite the availability of effective chemotherapy, 3.5 million TB deaths occur each year.

   Re-emergence of tuberculosis: strategies and treatment

   pubmed.ncbi.nlm.nih.gov/11829709/

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   What is the treatment plan for inactive tuberculosis (TB)?

   • You and your health care provider will discuss which treatment plan is best for you. Treatment for inactive TB can take three, four, six, or nine months depending on the treatment plan. The treatment plans for inactive TB use different combinations of medicines that may include: Keep Reading: Treating Inactive Tuberculosis

   Treating Tuberculosis | Tuberculosis (TB) | CDC

   www.cdc.gov/tb/treatment/index.html

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   What are the treatment plans for drug-resistant TB disease?

   • There are several treatment plans for drug-resistant TB disease depending on what medicines the TB germs are resistant to. Treating and curing drug-resistant TB disease is complicated. It should be treated by a TB medical expert. People with drug-resistant TB disease must be treated with special medicines.

   Treating Tuberculosis | Tuberculosis (TB) | CDC

   www.cdc.gov/tb/treatment/index.html

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   How long should MDR tuberculosis be treated?

   • The appropriate duration of treatment for MDR tuberculosis also remains to be defined. The WHO recommends a minimum of 20 months (including the induction phase), but this recommendation is based on a database that included few patients treated for shorter periods.

   Treatment of Tuberculosis | New England Journal of Medicine

   www.nejm.org/doi/full/10.1056/NEJMra1413919

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3. www.clinicalmicrobiologyandinfection.com › articleThe re-emergence of tuberculosis: what have we learnt from ...

   www.clinicalmicrobiologyandinfection.com › article

   Tuberculosis (TB) has re-emerged over the past two decades: in industrialized countries in association with immigration, and in Africa owing to the human immunodeficiency virus epidemic. Drug-resistant TB is a major threat worldwide.

   • Author: M.W. Borgdorff, D. van Soolingen

   • Publish Year: 2013

4. pubmed.ncbi.nlm.nih.gov › 11829709Re-emergence of tuberculosis: strategies and treatment

   pubmed.ncbi.nlm.nih.gov › 11829709

   The worldwide spread of TB is mainly caused by the emergence of multidrug-resistant (MDR) M. tuberculosis strains, thus underlining the need for novel antimycobacterial drugs with improved efficacy. Research in TB chemotherapy, as well as in vaccine development, has entered an intense phase in an attempt to combat this disease.

   • Author: Laurent Kremer, Gurdyal S Besra

   • Publish Year: 2002

5. www.ncbi.nlm.nih.gov › pmc › articlesMajor factors affecting the emergence and re-emergence of ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Mar 1, 2005 · Multidrug-resistant M tuberculosis (M-DRTB) has also developed significant resistance to rifampin and isoniazid, drugs that have been the cornerstone of effective treatment. Outbreaks of M-DRTB have been reported in New York City and many parts of the developing world [48] , [152] .

   • Author: Deirdre L. Church

   • Publish Year: 2004

6. www.ncbi.nlm.nih.gov › pmc › articlesRecurrent tuberculosis: a systematic review and meta-analysis ...

   www.ncbi.nlm.nih.gov › pmc › articles

   A recurrent tuberculosis (TB) episode results from exogenous reinfection or relapse after cure. The use of genotyping allows the distinction between both. Methods.

   • Author: Victor Vega, Sharon Rodríguez, Patrick Van der Stuyft, Carlos Seas, Carlos Seas, Larissa Otero, Lari...
   • DOI: 10.1136/thoraxjnl-2020-215449

   • Publish Year: 2021
   • Published: 2021/05

7. www.ncbi.nlm.nih.gov › pmc › articlesRisk factors for recurrent tuberculosis after successful ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Oct 23, 2020 · People successfully completing treatment for tuberculosis remain at elevated risk for recurrent disease, either from relapse or reinfection. Identifying risk factors for recurrent tuberculosis may help target post-tuberculosis screening and care.

   • Author: Patrick George Tobias Cudahy, Patrick George Tobias Cudahy, Douglas Wilson, Ted Cohen
   • DOI: 10.1186/s12879-020-05515-4

   • Publish Year: 2020
   • Publication: BMC Infect Dis. 2020; 20: 789.

8. www.cdc.gov › tb › treatmentTreating Tuberculosis | Tuberculosis (TB) | CDC

   www.cdc.gov › tb › treatment

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   May 6, 2024 · Treatment options. There are several safe and effective treatment plans recommended in the United States for inactive TB and active TB disease. A treatment plan (also called treatment regimen) for inactive TB or active TB disease is a schedule to take TB medicines to kill all the TB germs.

9. www.nejm.org › doi › fullTreatment of Tuberculosis | New England Journal of Medicine

   www.nejm.org › doi › full

   Nov 26, 2015 · Recent studies suggest that in many patients, Mycobacterium tuberculosis bacteria are sequestered in compartments that are inaccessible to antibiotic action; this could explain the poor long-term...