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  1. Jun 5, 2024 · Depending on the type of nerve pain, some creams that may be effective are Raitera Neuropathy Relief Cream, Penetrex Pain Relief Therapy, and Biofreeze Pain Relief Gel. These creams contain natural cure to relieve nerve pain, inflammation or numbness which are always affiliated with excited nerves.

    • Overview
    • What causes nerve pain?
    • OTC nerve pain medication options
    • What pain reliever is best for nerve pain?
    • Bottom line

    Some over-the-counter (OTC) topical creams, like lidocaine or capsaicin, may be helpful for nerve pain.

    Nerve pain is distinct from typical tissue pain. When you have tissue pain, like falling down or getting a cut, your nerves deliver the pain message to your brain.

    But when the nerves themselves become irritated or damaged, they become the source of pain. This type of pain can be severe and more difficult to treat.

    Nerve pain is typically treated with prescription-strength medications, but some over-the-counter products, primarily topical creams and ointments, can help take the edge off.

    Nerve pain, or neuropathy, is when the nerves that carry information to and from the brain and spinal cord become damaged, leading to symptoms like

    •pain

    •numbness

    •tingling

    •weakness in the affected areas

    Common conditions causing neuropathy include:

    Nerve pain can be difficult to treat since it affects the nerve itself. This pain can be quite severe and debilitating, causing numbness, tingling, and stinging.

    Typical over-the-counter (OTC) pain relievers, like acetaminophen (Tylenol) and ibuprofen (Advil), aren’t very effective for nerve pain, and most people will need prescription-strength medications.

    Typical OTC oral medications and nonsteroidal anti-inflammatory drugs (NSAIDs) aren’t very effective for neuropathy.

    Rather, medications like anticonvulsants, antidepressants, and opioids are often used to treat nerve pain. These medications work by targeting the nervous system and helping to reduce the perception of pain signals.

    Based on research-based evidence, first-line medications for neuropathy include:

    •gabapentinoids — a subclass of anticonvulsants (gabapentin, pregabalin)

    •tricyclic antidepressants (amitriptyline)

    •selective-serotonin-norepinephrine reuptake inhibitors (duloxetine, venlafaxine)

    If your nerve pain is chronic or severe, you’ll likely need prescription-strength medications because common OTC medications, like ibuprofen, aspirin, and acetaminophen aren’t very effective for nerve pain.

    Still, certain OTC topical options, like capsaicin or lidocaine cream, may be helpful if your pain is mild or if you use them along with prescription medications.

    • Traci Pedersen
  2. Topical agents (such as lidocaine patches or cream) are of modest efficacy but may add symptomatic relief in selected patients with neuropathic pain and have the advantage of minimal side effects.

  3. Jan 16, 2020 · This randomized, placebo-controlled study examined the effect of vitamin D replacement therapy on neuropathic symptoms and balance in patients with diabetic neuropathic pain and low vitamin D levels.

    • Aylin Sari, Zeynep Akdoğan Altun, Cigdem Arifoglu Karaman, Basak Bilir Kaya, Bekir Durmus
    • 10.2147/JPR.S203176
    • 2020
    • J Pain Res. 2020; 13: 171-179.
  4. Feb 10, 2016 · Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.

    • Abdul Basit, Khalid Abdul Basit, Asher Fawwad, Fariha Shaheen, Nimra Fatima, Ioannis N Petropoulos, ...
    • 2016
  5. May 26, 2022 · One way of resolving this problem is with topical neuropathy creams. These can be applied to the painful area, like the feet, to deliver quick and effective pain relief. These creams are generally affordable, readily available, and painless to apply.

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  7. Oct 29, 2021 · Vitamin D deficiency has been reported to be associated with diabetic peripheral neuropathy (DPN). Our objective here was to evaluate the association between vitamin D levels and neuropathic symptoms in a Chinese population. Material/Methods.

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