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related to: von willebrand disease treatment in childrenVisit BleedingDisorders.com to learn about available treatment options for VWD. Learn more about treating von Willebrand disease today.
Visit the HCP site to view safety information for a treatment for VWD in adults.
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What is the treatment for a child with von Willebrand disease?
What is von Willebrand disease?
What is Stimate used for in children with von Willebrand disease?
Jan 12, 2021 · Major therapies include use of desmopressin to induce endothelial release of stored von Willebrand factor (VWF) and factor VIII (FVIII) and use of VWF concentrates, including both plasma-derived and recombinant products, as well as adjuvant therapies, such as antifibrinolytic tranexamic acid.
- Nathan T. Connell, Veronica H. Flood, Romina Brignardello-Petersen, Rezan Abdul-Kadir, Alice Arapshi...
- 2021
For more serious bleeding, Stimate, given intravenously, or desmopressin acetate (DDAVP), given via nasal spray, is the treatment of choice when a child has been diagnosed with mild von Willebrand disease. Stimate or DDAVP are used to boost the child’s own factor 8 and von Willebrand factor levels.
The deficiency in this protein results in mucocutaneous bleeding, and post-traumatic or postsurgical bleeding. Diagnosing VWD may be problematic because of fluctuating clotting factor levels. The pathophysiology, laboratory diagnosis, and treatment of children and adolescents with VWD are discussed.
- Robert J Klaassen, Jacqueline M Halton
- 10.1093/pch/7.4.245
- 2002
- 2002/04
Tell the patient she does not meet criteria for a diagnosis of VWD because her VWF levels are greater than 30 IU/mL. Diagnose the patient with type 1 VWD and arrange for desmopressin trial with VWF levels 1- and 4-hours post administration. Diagnose the patient with type 1 VWD and obtain a VWF propeptide level.
- How Does The Blood Normally Clot After Injury?
- What Is Von Willebrand Disease?
- What Is Hemophilia?
- What If My Child Has Symptoms Or Episodes of Abnormal bleeding?
- More Information
Some injuries to the body cause breaks in blood vessels, the tubes that carry blood. The broken blood vessels contract or narrow to decrease the blood flow out of the body. Then, cells in the blood called platelets plug the holes by sticking to the blood vessel and to other platelets with the help of a protein called von Willebrand factor (vWF). To...
Von Willebrand disease (vWD) is a group of bleeding disorders caused by problems with a blood clotting protein called von Willebrand factor (vWF). vWD can be inherited in an "autosomal dominant" way. This means that if one parent has vWD, then there is a 50% chance of passing it on to each child. The most common inherited type of vWD is type 1 vWD....
The hemophilias are a group of inherited bleeding disorders caused by deficient or missing clotting factors called Factor VIII deficiency (or Hemophilia A) or Factor IX deficiency (or Hemophilia B). Without these clotting factors, a stable blood clot cannot form and a child with hemophilia can have severe bleeding symptoms at birth. Hemophilia A an...
If your child at any age has mild bleeding symptoms, contact your pediatrician for a complete and thorough evaluation. If your child experiences severe bleeding symptoms, try to control the bleeding by applying pressure, and immediately contact your pediatrician or seek medical attention at your nearest emergency department. Most children with blee...
What is a Pediatric Hematologist/Oncologist? Von Willebrand Disease (vWD)(National Center on Birth Defects and Developmental Disabilities)The most commonly used treatments include: Desmopressin (DDAVP): A synthetic hormone given by an injection into a vein or through a nasal spray called Stimate®. DDAVP causes an increased release of VWF from blood vessel cells. It is usually effective for most patients with type 1 and some with type 2 VWD.
There are 3 main types of VWD: Type 1. This is the mildest and most common form. Your child has low levels of von Willebrand factor and may have low levels of factor VIII. Type 2. There are 4 subtypes of Type 2 VWD. Each is treated differently. Your child has von Willebrand factor in the blood, but it doesn't work normally. Type 3.
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related to: von willebrand disease treatment in childrenVisit BleedingDisorders.com to learn about available treatment options for VWD. Learn more about treating von Willebrand disease today.
Visit the HCP site to view safety information for a treatment for VWD in adults.
