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Oct 26, 2021 · The usual cause of von Willebrand disease is an inherited abnormal gene that controls von Willebrand factor — a protein that plays a key role in blood clotting. When you have low levels of this protein or it doesn't work as it should, small blood cells called platelets cannot stick together properly nor attach themselves normally to the blood ...
May 15, 2024 · Key points. With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. Close monitoring throughout pregnancy is important for women with VWD. Women with VWD are at risk for serious bleeding after delivery. Pregnancy and childbirth.
Von Willebrand disease (VWD), the most frequent autosomal inherited bleeding disorder, is caused by quantitative or qualitative defects of von Willebrand factor (VWF), an adhesive protein that binds platelets to exposed sub-endothelium and carries factor VIII (FVIII) in circulation 1, 2.
- Giancarlo Castaman, Paula D. James
- 10.1111/ejh.13250
- 2019
- 2019/08
May 20, 2019 · Given the wide heterogeneity of phenotypes and of the underlying pathophysiological mechanisms associated with the disorder, pregnancy and delivery in von Willebrand disease (VWD) represent a significant clinical challenge.
- Giancarlo Castaman, Paula D. James
- 2019
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Does von Willebrand disease affect pregnancy and delivery?
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What is von Willebrand disease?
Stressful situations, hormone levels during pregnancy, and the use of oral contraceptives increase the production of von Willebrand factor 2 to 3 fold and reduce the chances of abnormal bleeding during periods, pregnancy (especially in later trimesters), and labor.
May 15, 2024 · Von Willebrand disease (VWD) is a blood disorder in which the blood does not clot properly. VWD is the most common bleeding disorder. Signs of VWD include nosebleeds, easy bruising, heavy menstrual bleeding, and longer than normal bleeding after injury, surgery, dental work, or childbirth.
Abstract. A 26-year-old woman (gravida 1) was seen when she was 33½ weeks pregnant. She was healthy except for easy bruising, which had been a problem since childhood. The patient did not have nosebleeds or prolonged bleeding after toothbrushing, flossing, or minor cuts. Menarche had occurred at age 13, with a 28-day cycle.
