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Jun 7, 2022 · Von Willebrand disease (VWD), first described by Dr. Erik von Willebrand, is the most common autosomal inherited bleeding disorder. It is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury, and binds and stabilizes blood clotting factor ...
Nov 5, 2020 · During pregnancy, the hemostatic balance is changing toward a procoagulant state in order to be prepared for blood loss during delivery and the postpartum period. 4-8 This procoagulant state is caused by a physiological increase of many coagulation factors, including factor VIII (FVIII) and von Willebrand factor (VWF) with a peak shortly before giving birth. 7 The procoagulant state is also ...
- Frank W G Leebeek, Johannes Duvekot, Marieke J H A Kruip
- 2020
May 15, 2024 · Pregnancy and childbirth. With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. A woman who has VWD should be monitored closely throughout her pregnancy by her doctors. It is important for a woman's health care providers to be aware that she has VWD so that plans can be made for a ...
Von Willebrand disease (VWD) is a clotting disorder characterized by a quantitative or qualitative deficiency of the Von Willebrand factor (VWF) . Synthesized in endothelial cells and megakaryocytes, VWF plays a key role in primary and secondary hemostasis through its interaction with various platelet adhesion and aggregation receptors.
Dec 10, 2021 · VWD is a genetically and clinically heterogeneous bleeding disorder caused by a deficiency or an abnormality in the function of von Willebrand factor. Understanding inheritance pattern, hemostatic response to pregnancy, and response to treatment is essential for provision of individualized obstetric care and optimal outcome.
May 15, 2024 · What it is. Von Willebrand disease (VWD) is a blood disorder in which the blood does not clot properly. Blood contains many proteins that help the blood clot when needed. One of these proteins is called von Willebrand factor (VWF). People with VWD either have a low level of VWF in their blood or the VWF protein doesn't work the way it should.
Oct 26, 2021 · Rarely, von Willebrand disease can develop later in life in people who didn't inherit an affected gene from a parent. This is known as acquired von Willebrand syndrome, and it's likely caused by an underlying medical condition. Risk factors. The main risk factor for von Willebrand disease is having a family history of it.
