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The variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF, prompts a careful evaluation of pregnant women with VWD to plan the most appropriate treatment at the time of parturition.
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Given the wide heterogeneity of phenotypes and of the...
- Mcmdm-1Vwd
Introduction. von Willebrand factor (VWF) is a multimeric...
- Table 1
Jun 7, 2022 · Although VWD occurs equally in males and females, women are at a higher risk of being affected, mostly because of bleeding challenges associated with menstruation, pregnancy, and childbirth [ 1, 7, 8 ]. During pregnancy, many changes in hemostasis occur that result in a hypercoagulable state.
Apr 16, 2024 · Treatment during pregnancy and childbirth — Many people with VWD who become pregnant can have a normal pregnancy without bleeding complications. However, as with surgery, it is important to have proper monitoring and to know what treatments will work well for you if you do have excessive bleeding.
May 15, 2024 · Key points. With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. Close monitoring throughout pregnancy is important for women with VWD. Women with VWD are at risk for serious bleeding after delivery.
This case underscores the significance of specialized management for Von Willebrand disease during pregnancy and childbirth, emphasizing adherence to institutional protocols involving specific hemostatic factors.
In type 1—which is the most common by far, accounting for approximately 75% of cases—the level of von Willebrand factor (VWF) is low, but the protein functions normally. In type 2, which accounts for approximately 20% of cases, the VWF level may be normal, but the protein functions abnormally.
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Objective: von Willebrand disease (VWD) is a hereditary bleeding disorder. Type 3 VWD is the most severe and rare phenotype that presents many challenges for management of pregnant women. The aim of this study was to review the maternal characteristics and complications in pregnant women with Type 3 VWD.
