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General guidelines for the treatment of women with von Willebrand disease at delivery. Since pregnant women with VWD are at increased risk of postpartum hemorrhage if untreated 9,17,27,31, treatment options should be planned at the beginning of pregnancy.
- Table 1
Given the wide heterogeneity of phenotypes and of the...
- Mcmdm-1Vwd
Introduction. von Willebrand factor (VWF) is a multimeric...
- Table 1
May 20, 2019 · The variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF, prompts a careful evaluation of pregnant women with VWD to plan the most appropriate treatment at the time of parturition.
- Giancarlo Castaman, Paula D. James
- 2019
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Does von Willebrand disease cause bleeding events during pregnancy and childbirth?
Does von Willebrand disease cause postpartum hemorrhage?
Can a woman with von Willebrand disease have a vaginal delivery?
Does von Willebrand disease cause heavy menstrual bleeding?
Nov 5, 2020 · Women with inherited bleeding disorders, including carriers of hemophilia A and B, or with von Willebrand disease, have an increased risk of bleeding during pregnancy and delivery. The unborn child may also be affected by the bleeding disorder for which specific measures have to be considered.
- Frank W G Leebeek, Johannes Duvekot, Marieke J H A Kruip
- 2020
Jan 10, 2022 · von Willebrand disease (VWD) disproportionately affects women because of the potential for heavy menstrual bleeding (HMB), delivery complications, and postpartum hemorrhage (PPH). To systematically synthesize the evidence regarding first-line management of HMB, treatment of women requiring or desiring neuraxial analgesia, and management of PPH.
An autosomally inherited congenital bleeding disorder, von Willebrand disease involves a qualitative or quantitative deficiency of von Willebrand factor (vWF), a protein critical for proper platelet adhesion and protection against coagulant factor degradation.
May 15, 2024 · With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. Close monitoring throughout pregnancy is important for women with VWD. Women with VWD are at risk for serious bleeding after delivery.
Von Willebrand disease is a prevalent condition in females of childbearing age, and during pregnancy, it is associated with a higher risk of postpartum bleeding, exposure to massive transfusion protocols, pulmonary edema, acute renal injury, postpartum bleeding-related maternal mortality, and transfusion-related complications .
