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It was in Leuckart's laboratory that he made his first scientific discovery of alternation of generations (sexual and asexual) in nematodes ( Chaetosomatida) and then at the University of Munich. In 1865, while at Giessen, he discovered intracellular digestion in flatworm, and this study influenced his later works.
Aug 1, 2016 · How did Metchnikoff's research lay the foundations for current study in your field, and how have his discoveries evolved over the past 100 years?
- David M. Underhill, Siamon Gordon, Beat A. Imhof, Gabriel Núñez, Philippe Bousso
- 2016
Jun 15, 2016 · Originally a zoologist, Metchnikoff started his impressive scientific work as a developmental embryologist under the strong influence of Darwin’s “On the Origin of Species” published in the year 1859. By describing phagocytes and phagocytosis, he discovered one of the most intriguing mechanisms of innate immunity.
Aug 25, 2016 · The life and work of Elie Metchnikoff (1845–1916) is a study of contrasts, pessimism followed by optimism, from Imperial Russia to the Pasteur Institute, comparative embryology to experimental pathology. And yet his discovery of the significance of phagocytosis reveals an underlying continuity, which serves as a thread from intracellular ...
- Siamon Gordon
- 2016
Nov 1, 2003 · Metchnikoff receded as a founder of the subject, and although phagocyte pathophysiology became an active area of investigation in its own right, the lymphocyte and its products dominated...
- Alfred I. Tauber
- 2003
Elie Metchnikoff, a Russian scientist who was the first to discover phagocytosis, a cell-mediated immune response to foreign matter. Prior to his findings, white blood cells, for example, were thought to take up bacteria not to fight disease, but to spread it. Metchnikoff showed instead that such cells, called phagocytes, could engulf and destroy
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Nov 27, 2008 · Metchnikoff is rightly famous for his recognition of the biological significance of leukocyte recruitment and phagocytosis of microbes in host defence against infection, inflammation and immunity. As a comparative zoologist he utilised a broad range of model organisms for microscopic studies in vivo and in vitro.
