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Ampicillin/sulbactam is a fixed-dose combination medication of the common penicillin-derived antibiotic ampicillin and sulbactam, an inhibitor of bacterial beta-lactamase. Two different forms of the drug exist.
Jan 11, 2024 · The ampicillin/sulbactam combination demonstrates synergy in addressing bacterial strains resistant to ampicillin, thus providing broader coverage. This drug combination incorporates a β-lactamase inhibitor into ampicillin, extending coverage against potentially resistant bacteria.
- Basil V. Peechakara, Mohit Gupta
- 2024/01/11
- Cleveland Clinic Foundation
Penicilinat ( P, PCN ose PEN) janë një grup antibiotikësh β-laktam të marrë fillimisht nga mykët Penicillium, kryesisht P. chrysogenum dhe P. rubens. Shumica e penicilinave në përdorim klinik sintetizohen nga P. chrysogenum duke përdorur fermentim të thellë në rezervuar [2] dhe më pas pastrohen.
Sulbactam is primarily used as a suicide inhibitor of β-lactamase, shielding more potent beta-lactams such as ampicillin. Sulbactam itself contains a beta-lactam ring, and has weak antibacterial activity by inhibiting penicillin binding proteins (PBP) 1 and 3, but not 2.
Ampicillin and sulbactam combination is an antibiotic that belongs to the group of medicines known as penicillins and beta-lactamase inhibitors. It works by killing the bacteria and preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.
Ampicillin is an antibiotic belonging to the aminopenicillin class of the penicillin family. The drug is used to prevent and treat a number of bacterial infections, such as respiratory tract infections, urinary tract infections, meningitis, salmonellosis, and endocarditis. [7]
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Feb 17, 2020 · Based on the IDSA and ATS guidelines for the management of adults with hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), ampicillin/sulbactam is effective and recommended for the treatment of HAP or VAP caused by susceptible Acinetobacter spp. Surgical prophylaxisyes.
