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How is aggressive angiofollicular lymph node hyperplasia (Castleman's disease) treated?
What is enlarged lymph node (UCD)?
Aug 3, 2016 · Aggressive angiofollicular lymph node hyperplasia (Castleman’s disease) treated with high dose melphalan and autologous bone marrow transplantation. Hematol Oncol. 1986; 4 (3):213–217.
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Cates GW, Robinson CL. Angiofollicular mediastinal lymph...
- IMRT
Introduction. Castleman’s Disease (CD) was first described...
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Proliferation occurs in a single lymph node or region of...
- A Case Report
A 75% decrease in lymph nodes and splenomegaly was noted. In...
- Radiotherapy of Unicentric Mediastinal Castleman's Disease
Lymph node hyperplasia was then considered, supporting the...
- Radiation Therapy in The Treatment of Unicentric Castleman's Disease
The patient was admitted for further investigation. A CT...
- Refractory Uveitis in Patient With Castleman Disease Successfully Treated With Tocilizumab
Panel (a) shows the thoracic X-ray photograph before...
- HHV-8–Associated Multicentric Castleman's Disease in HIV-Negative Patient
A lymph node biopsy revealed HHV-8–associated MCD (Fig. 1...
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Unicentric Castleman disease typically occurs in children and young adults (3rd and 4th decades), with a slight female predominance (1.4:1) 15. Multicentric Castleman disease, on the other hand, occurs in an older population (5th and 6th decades), with a slight male predominance 15. HIV is a relevant risk factor for this condition, and it has been ...
Unicentric Castleman disease is usually asymptomatic and incidentally found on routine exams for other reasons. Depending on the anatomical site, a painless lymphadenopathy may be noted. Multicentric Castleman disease has an exuberant clinical presentation due to the systemic inflammation, with symptoms such as fevers, night sweats, fatigue, and we...
The disease is of unknown etiology, but the most widely accepted theory is that Castleman disease is a chronic low-grade inflammatory process. The interleukin 6 in unicentric Castleman disease and both interleukin-6 and HHV-8 in multicentric Castleman disease are demonstrated to play a critical role in pathogenesis and symptomatology of the disease...
Thoracic lesions may present as mediastinal masses. Additional findings include the following 19: 1. displacement of adjacent structures due to mass effect 2. ipsilateral pleural effusion 3. periosteal reaction Both hyaline-vascular and plasma cell types present as hypoechoic masses and nodules 17. The ultrasonographic findings are non-specific and...
Treatment for unicentric Castleman disease is surgical, with a good prognosis (can be curative). Multicentric Castleman disease may be treated with any combination of surgery, chemotherapy and prednisolone 6. Available treatments include also antiviral strategies (targeting HHV-8), and monoclonal antibody therapies targeting CD20 or IL-6 15. The pr...
The condition was first described by an American pathologist, Benjamin Castleman (1906-1982) in 1954 4,20.
For mediastinal lesions, consider the differential by location: 1. differential for an anterosuperior mediastinal mass 2. differential for a posterior mediastinal mass
Surgery is considered by experts to be the first-line treatment option for all cases of UCD. Sometimes, removing the enlarged lymph node(s) is not possible. If surgical excision is not possible, treatment is recommended for symptomatic patients. If symptoms are due to compression, then rituximab is recommended.
Aug 3, 2016 · Tocilizumab therapy resulted in significant reduction in lymphadenopathy (30% reduction in the mean short axis of involved lymph nodes) for 52% of patients after 1 year of treatment. Marked improvement was also seen in biochemical measures such as CRP and fibrinogen in 64% and 71% of patients, respectively.
Jun 16, 2022 · Unicentric Castleman disease (UCD) involves a single enlarged lymph node or single region of enlarged lymph nodes whereas multicentric Castleman disease (MCD) involves multiple regions of enlarged lymph nodes. There are two subtypes of MCD. One subtype is caused by human herpesvirus-8 (HHV-8; also known as Kaposi sarcoma–associated herpesvirus).
May 3, 2024 · Request an Appointment. Symptoms & causes. Diagnosis & treatment. Doctors & departments. Overview. Castleman disease is a rare disorder that involves an overgrowth of cells in your body's lymph nodes. The most common form of the disorder affects a single lymph node, usually in the chest or abdomen. This form is called unicentric Castleman disease.
Apr 21, 2022 · Literature review current through: Feb 2024. This topic last updated: Apr 21, 2022. INTRODUCTION. Castleman disease (CD, angiofollicular lymph node hyperplasia) describes a heterogeneous group of lymphoproliferative disorders that share common histopathologic features.
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