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  1. Jul 24, 2018 · The pathway that goes upward carrying sensory information from the body via the spinal cord towards the brain is defined as the ascending pathway, whereas the nerves that goes downward from the brain to the reflex organs via the spinal cord is known as the descending pathway. Pain is a vast subject and affects so many regions of an individual ...

  2. Sep 10, 2023 · Pain is a somatic and emotional sensation which is associated with actual or potential tissue damage. Pain is critical for survival and has a major evolutionary advantage. This is because behaviours which cause pain are often dangerous and harmful, therefore they are generally not reinforced and are unlikely to be repeated. The classification of pain is complicated and there are many different ...

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  4. 4 Pain transmission can be modulated at a number of levels, including the dorsal horn of the spinal cord and via descending inhibitory pathways. 5 The spinothalamic and spinoreticular tracts are important ascending pain pathways 6 Neuropathic pain can be spontaneous and is often described as burning, shooting, or stabbing

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  5. “referred pain.” Modulation: Altering or Blocking the Pain Signal as It Travels Through Spinal Cord, Medulla, Pons, and Midbrain to the Cerebral Cortex Modulation is the way the brain (descending path-way) alters the intensity of the signal traveling up the ascending pathway depending on the circumstance

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  6. This article provides an overview of the physiological mechanisms of pain and the important pain pathways. We will discuss pain receptors, transmission of pain signals to the spinal cord and pain pathways within the spinal cord. We will look at how pain can be modulated at different levels along the pathway, and the sites of action of analgesic ...

  7. Vol. 16, No. 3, July-Sept 2005 PAIN PROCESSING 279 Figure 1. Ascending pain pathway. The ascending pain pathway transmits nociceptive information from peripheral tissues (1) via a primary afferent nerve fiber, which enters the spinal cord in the dorsal horn (2) where it synapses with a second-order neuron. The second-order neuron travels up

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