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  2. Feb 22, 2019 · Intervention: Melatonin. Daily dose: 2 mg of controlled release and 3–12 mg standard melatonin. Duration of the included studies were 7 weeks (included 2 × 3 week intervention periods with one week between in one study, and 15 days in the other study. Comparator: No change in treatment.

    • Casey Gray, Andrea Ryce
    • 2019/02/22
    • 2019
    • Is Melatonin Safe For Long-Term use?
    • What Type of Melatonin Supplement Is Best?
    • When Should I Take Melatonin?
    • Who Shouldn’T Take Melatonin?

    According to the National Center for Complementary and Integrative Health, more research is needed to determine whether melatonin is safe for long-term use (21). If you find that you’re relying on nightly doses, it may be more effective to talk with a healthcare professional about any potential underlying sleep disorders or health conditions that m...

    In short, it depends on what you’re looking for. Each form has pros and cons. Capsules and tablets have a longer shelf life than other forms. However, liquids and powders may be easier for some people to take.

    Studies evaluating the effects of melatonin on sleep have administered melatonin up to 2 hours before bedtime. It’s best to follow the instructions on the supplement label (23). Melatonin has a half-life of 1–2 hours, depending on the formulation. The half-life is the time required for the amount of a substance in the body to be reduced by half (23...

    The National Institutes of Health cautions that there’s a lack of research on the effects of melatonin during pregnancy and breastfeeding, so those who are pregnant or nursing may want to avoid melatonin supplements (23). Melatonin is also not recommended for those with certain medical conditions, such as kidney disease. Those with epilepsy and tho...

  3. Dec 21, 2023 · 1. Best Overall Melatonin. Thorne Melaton-3. $13 at Amazon. Read more. 2. Best Value Melatonin. Nature Made Melatonin 3mg Tablets. $9 at Amazon. Read more. 3. Best Low-Dose...

  4. www.mayoclinic.org › drugs-supplements-melatoninMelatonin - Mayo Clinic

    Aug 10, 2023 · Your body likely produces enough melatonin for its general needs. However, evidence suggests that melatonin supplements promote sleep and are safe for short-term use. Melatonin can be used to treat delayed sleep phase and circadian rhythm sleep disorders in the blind and provide some insomnia relief.

  5. Feb 10, 2021 · Evidence-based recommendations published by the AASM indicate that strategically timed melatonin can be a treatment option for some problems related to sleep timing, such as jet lag disorder and shift work disorder.

  6. Evidence-Based Answer. Melatonin preparations reduce sleep-onset latency, increase total sleep time, and slightly improve sleep efficiency. (Strength of Recommendation [SOR]: B, based on...

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