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    • Phentermine (Adipex-P and Lomaira) Phentermine is one of the most widely used prescription weight loss medications in the United States and has been around since the 1950s.
    • Qsymia (Phentermine and Topiramate) This popular weight loss pill contains phentermine combined with a migraine medication called topiramate. Research shows combining these two drugs may result in greater weight loss than either alone.
    • Contrave (Naltrexone and Bupropion) Contrave is another FDA-approved prescription-only weight loss medication that combines naltrexone and bupropion.
    • Orlistat (Xenical) Orlistat is another FDA-approved prescription weight loss medication in capsule form. You may be familiar with Orlistat’s over-the-counter version, Alli, available at a lower dose.
  1. Learn which weight-loss pills won't affect blood pressure, including fat-blocking over-the-counter meds and prescriptions drugs meant to help you lose weight.

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    • Oral Semaglutide
    • Orforglipron
    • Danuglipron
    • Aph-012
    • Ard-101
    • Oral Amycretin
    • Retatrutide
    • Cagrisema
    • Ecnoglutide
    • Mazdutide

    What it is: Oral semaglutide is a glucagon-like peptide-1 (GLP-1) agonist. It mimics the effects of GLP-1, a gut hormone that's involved in blood glucose (sugar) control, digestion, and appetite management. How it’s administered:Oral semaglutide is a tablet that’s taken once daily. Status:Novo Nordisk — the manufacturer of oral semaglutide — was re...

    What it is: Orforglipronis an oral GLP-1 agonist. Unlike injectable GLP-1 agonists, it’s made of chemicals — not peptides (amino acid chains). This helps it survive in your stomach better. How it’s administered:Orforglipron is an oral capsule that’s taken once daily. Status: A phase 3 study for orforglipron is underwayfor chronic weight management ...

    What it is: Danuglipronis an oral GLP-1 pill. It works the same way as orforglipron. How it’s administered:Danuglipron is an oral tablet. Initially studied as a twice-daily medication, a once-daily version is now in development. Status:Danuglipron recently completed its phase 2 studies. But the data was mixed, so Pfizer — danuglipron’s manufacturer...

    What it is: APH-012 is an oral medicine that imitates the metabolic effects of gastric bypass (weight loss) surgery. It’s a glucose pillthat’s designed to stimulate certain parts of your small intestine. How it’s administered:APH-012 is a once-daily oral medication. Its manufacturer is calling it a distal jejunal-release dextrose bead. Status: APH-...

    What it is: ARD-101 is an oral medication. It targets “bitter taste receptors” in your gut and activates appetite-suppressing hormones such as GLP-1, glucagon-like peptide-2 (GLP-2), and cholecystokinin. How it’s administered:ARD-101 is an oral pill that’s taken twice daily. Status: ARD-101 is enrolled in three phase 2 studies. Two are already comp...

    What it is: Amycretin is an oral medication that’s being developed for chronic weight management. It’s a dual GLP-1 and amylin agonist. Amylinis a hormone that helps you feel more full after meals. How it's administered:Amycretin is a once-daily oral tablet. But an under-the-skin amycretin injection is being developed too. Status: Amycretin complet...

    What it is: Retatrutide is a medication that’s being studied for weight loss and Type 2 diabetes in adults. Retatrutide works by attaching to three receptors (proteins): GIP (glucose-dependent insulinotropic polypeptide), GLP-1, and glucagon. How it’s administered:Retatrutide is an injectable medication that’s administered under the skin once weekl...

    What it is:CagriSema is a combination treatment that combines two injectable medications (cagrilintide and semaglutide) into one. Cagrilintide mimics amylin, while semaglutide mimics GLP-1. How it’s administered:CagriSema is an injectable medication that’s administered under the skin once weekly. Status: A phase 3 weight loss study started in Novem...

    What it is: Ecnoglutide is another GLP-1 agonist; it’s thought to be a longer-lasting alternative to Saxenda(liraglutide). Saxenda is a once daily, injectable GLP-1 agonist that’s approved for weight loss. How it’s administered:Ecnoglutide is an injectable medication that’s administered under the skin once weekly. Status: Ecnoglutide is being studi...

    What it is: Mazdutideis a GLP-1 agonist that also mimics glucagon. It’s being studied for weight loss and Type 2 diabetes in adults. How it’s administered:Mazdutide is an injectable medication that’s administered under the skin once weekly. Status:Mazdutide is enrolled in several phase 3 studies in China. They’re set to run through 2024 and 2025. E...

  3. Apr 1, 2024 · Some popular weight-loss pills are Contrave (naltrexone / bupropion), Qsymia (phentermine / topiramate ER), and phentermine (Adipex-P). Some clinical studies suggest that Qsymia is the most effective weight loss pill. However, it’s a controlled substance that may not be the best option for everyone.

  4. Feb 15, 2024 · Have a body mass index (BMI) of at least 30. Have a BMI of 27 with an additional medical condition such as high blood pressure, type 2 diabetes, or high cholesterol. This article will discuss eight current Food and Drug Administration (FDA)–approved weight loss drugs on the market.

  5. People with high blood pressure should exercise caution when considering the use of weight-loss drugs. This is because certain weight-loss drugs have the potential to increase blood pressure and lead to heart problems.

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  2. View Info About A Prescription Weight Management Injectable That May Help Treat Obesity. Access Patient Resources & Support Including Quick Start Guide & Savings Information.

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