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  2. Signs and symptoms. Signs and symptoms of CDI range from mild diarrhea to severe life-threatening inflammation of the colon.. In adults, a clinical prediction rule found the best signs to be significant diarrhea ("new onset of more than three partially formed or watery stools per 24-hour period"), recent antibiotic exposure, abdominal pain, fever (up to 40.5 °C or 105 °F), and a distinctive ...

  3. Clostridioides difficile ( syn. Clostridium difficile) is a bacterium known for causing serious diarrheal infections, and may also cause colon cancer. [4] [5] It is known also as C. difficile, or C. diff ( / siː dɪf / ), and is a Gram-positive species of spore -forming bacteria. [6]

  4. C. difficile infection can cause the colon to become inflamed. It sometimes can form patches of raw tissue that can bleed or make pus. Symptoms of severe infection include: Watery diarrhea as often as 10 to 15 times a day. Belly cramping and pain, which may be severe. Fast heart rate.

  5. Mar 6, 2024 · What it is. Clostridioides difficile [klos–TRID–e–OY-dees dif–uh–SEEL], formerly known as Clostridium difficile and often called C. difficile or C. diff., is a germ (bacterium) that causes diarrhea and colitis. Colitis is an inflammation of the colon.

  6. May 10, 2023 · What are the symptoms of C. diff infection? The most common symptom, and usually the first to appear, is watery diarrhea. A mild infection will cause diarrhea at least three times a day, often with some abdominal cramping or tenderness. As C. diff infection becomes more severe, diarrhea increases. It may occur as much as 10 to 15 times a day.

  7. A therapy known as bezlotoxumab (Zinplava) is a human antibody against C. difficile toxin B. It has been shown to cut the risk of repeat C. difficile infection in those at high risk of repeat episodes. Fecal microbiota transplant (FMT). FMT is a newer treatment for C. difficile infection that keeps coming back.

  8. Nov 14, 2022 · Loss of appetite/ weight loss. Dehydration. Rapid heart rate. If your C. diff infection is severe, you could get severe intestinal inflammation. Your colon could also get enlarged and you could ...

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