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  1. United States Department of Health and Human Services. Website. www .cdc .gov. The Centers for Disease Control and Prevention ( CDC) is the national public health agency of the United States. It is a United States federal agency under the Department of Health and Human Services, and is headquartered in Atlanta, Georgia.

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    During January–December 2022, the estimated 2022 U.S. age-adjusted death rate decreased by 5.3% to 832.8 per 100,000 persons, from 879.7 in 2021. Overall death rates were highest among males, older adults, and Black persons. The highest weekly numbers of overall deaths and COVID-19–associated deaths occurred during January and December. The three leading causes of death in 2022 were heart disease, cancer, and unintentional injury. COVID-19, the third leading cause of death in 2021, fell to fourth place in 2022 because of the large decrease in COVID-19–associated deaths compared with those in 2021 (7). The number of deaths caused by unintentional injury, largely driven by a high number of drug overdose deaths, remained high in 2022 compared with 2021 (8).

    Overall death rates and COVID-19–associated death rates decreased from 2021 to 2022 for most demographic groups, with the exception of certain age groups. COVID-19–associated death rates increased for all persons aged <15 years. Although the overall and COVID-19–associated death rates decreased for persons aged ≥85 years from 2021 to 2022, rates remained higher for this group compared with all other age groups. In addition, although overall and COVID-19–associated death rates decreased among all racial and ethnic groups, age-adjusted total and COVID-19–associated death rates remained high for Black and AI/AN persons compared with other groups. The current report did not examine death rates for causes of death other than COVID-19; however, available provisional data from the CDC WONDER platform indicate death rate patterns for leading causes of death (9). The age-adjusted rate of heart disease deaths increased for the third straight year since 2020. While the age-adjusted rate of cancer deaths had declined steadily during 1999–2020, the cancer death rate increased in 2021 and 2022. Further analysis of provisional data might offer additional insights into demographic patterns of leading causes of death.

    The findings in this report are subject to at least three limitations. First, data are provisional, and numbers and rates might change as additional information is received. Described changes in mortality trends might be underestimates. Second, timeliness of death certificate submission can vary by jurisdiction. As a result, the national distribution of deaths might be affected by the distribution of deaths reported from jurisdictions reporting later, which might differ from those in the United States overall. Finally, potential exists for misclassification of certain categories of race (i.e., AI/AN and Asian) and Hispanic ethnicity reported on death certificates (10). Thus, death rates for some groups might be under- or overestimated.

    This report provides an overview of provisional mortality in the United States during 2022. Provisional death estimates can offer researchers and policymakers an early signal about shifts in mortality trends and provide actionable information sooner than do the final mortality data, which are released approximately 11 months after the end of the data year. These data can guide public health policies and interventions aimed at reducing mortality directly or indirectly associated with the COVID-19 pandemic and among persons most affected, including persons who are older, male, or from members of certain racial and ethnic minority groups.

    Corresponding author: Farida B. Ahmad, fbahmad@cdc.gov.

    1National Center for Health Statistics, CDC.

    1.World Health Organization. ICD-10: international statistical classification of diseases and related health problems 10th revision. Geneva, Switzerland: World Health Organization; 2009. https://icd.who.int/browse10/2008/en

    2.CDC. National Center for Health Statistics: National Vital Statistics System. Instructions for classification of underlying and multiple causes of death – Section 1 – 2021. Hyattsville, MD: US Department of Health and Human Services, CDC, National Center for Health Statistics; 2021. https://www.cdc.gov/nchs/nvss/manuals/2a-sectioni-2021.htm

    3.CDC. National Center for Health Statistics. Technical notes: provisional death counts for coronavirus disease (COVID-19). Hyattsville, MD: US Department of Health and Human Services, CDC, National Center for Health Statistics; 2021. https://www.cdc.gov/nchs/nvss/vsrr/covid19/tech_notes.htm

    4.Heron M. Deaths: leading causes for 2017. Natl Vital Stat Rep 2019;68:1–77. PMID:32501203

    5.US Census Bureau. National population by characteristics: 2020–2021. Washington, DC: US Department of Commerce, US Census Bureau; 2021. https://www.census.gov/programs-surveys/popest/technical-documentation/research/evaluation-estimates/2020-evaluation-estimates/2010s-national-detail.html

    6.US Census Bureau. Methodology for the United States population estimates: vintage 2021. Washington, DC: US Department of Commerce, US Census Bureau; 2021. https://www2.census.gov/programs-surveys/popest/technical-documentation/methodology/2020-2021/methods-statement-v2021.pdf

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  3. Life expectancy: 77.5 years; Infant Mortality rate: 5.60 deaths per 1,000 live births; Source: Mortality in the United States, 2022, data tables for figures 1, 5 Number of deaths for leading causes of death:

  4. The CDC publishes official numbers of COVID-19 cases in the United States. The CDC estimates that, between February 2020 and September 2021, only 1 in 1.3 COVID-19 deaths were attributed to COVID-19. [2] The true COVID-19 death toll in the United States would therefore be higher than official reports, as modeled by a paper published in The ...

  5. Explore Leading Causes of Death - Data Filters. Data Years: 2022 Number of Causes: 10 Intent of Injury: All Deaths with drilldown to ICD codes Geography: United States Age Group Formats: 1-14 in 5-year groups; 15-65+ in 10-year groupsSex: Both Sexes Race: All Races Ethnicity: All Ethnicities Year and Race Options: 2001 - 2022 with No Race.

  6. Detailed mortality tables showing deaths, percent of total deaths, and death rates for the top 15 causes of death overall and by age group, race and Hispanic origin, sex, and state, with separate tables for infants. Leading Causes of Death, 1999-2015.

  7. CDC is the nation's leading science-based, data-driven, service organization that protects the public's health. CDC works 24/7 to protect America from health, safety and security threats, both foreign and in the U.S. About CDC. Organization and Mission. Leadership.