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    During January–December 2022, 244,986 deaths with COVID-19 listed as an underlying or contributing cause of death occurred among U.S. residents. The age-adjusted COVID-19 death rate was 61.3 per 100,000 persons. COVID-19–associated death rates were highest among males, older adults, and AI/AN persons. The COVID-19–associated age-adjusted death rate varied by HHS region, with the lowest rates in New England (Region 1) and highest rates in the south central United States (Region 6).

    Some demographic characteristics of COVID-19–associated deaths have remained similar since 2020; however, changes in other characteristics have occurred over time. During the first 2 years of the COVID-19 pandemic, for example, COVID-19 was listed as the underlying cause on approximately 90% of death certificates. In 2022, the percentage of deaths with COVID-19 as the underlying cause decreased to 76% (7). Changes were also observed in the setting where COVID-19 deaths are occurring. Whereas most COVID-19 deaths still occur in hospital inpatient settings, the proportion of those deaths decreased in 2022, as more deaths occurred in decedents’ homes and nursing homes or long-term care facilities.

    The findings in this report are subject to at least three limitations. First, data are provisional, and numbers and rates might change as additional information is received. Described changes in mortality trends might be underestimates. Second, timeliness of death certificate submission can vary by jurisdiction. As a result, the national or regional distribution of deaths might be affected by the distribution of deaths reported from jurisdictions reporting later, which might differ from those in the United States or in a region overall. Finally, potential exists for misclassification of certain categories of race (i.e., AI/AN and Asian) and Hispanic ethnicity reported on death certificates (8). Thus, death rates for some groups might be under- or overestimated.

    This report provides an overview of COVID-19–associated mortality in the United States in 2022 and highlights changes in the characteristics of COVID-19 deaths. These data provide updated information that advances understanding of the impacts of COVID-19 on mortality and how these have continued to shift during the course of the pandemic. These findings also help to guide public health policies and interventions intended to reduce severe COVID-19 impact by providing insight into groups that remain vulnerable to COVID-19–associated mortality.

    Corresponding author: Farida B. Ahmad, fbahmad@cdc.gov.

    1National Center for Health Statistics, CDC.

    1.World Health Organization. International statistical classification of diseases and related health problems, tenth revision (ICD–10). 2008 ed. Geneva, Switzerland: World Health Organization; 2009. https://icd.who.int/browse10/2008/en

    2.National Center for Health Statistics. National Vital Statistics System. Instruction manual, part 2a: instructions for classifying underlying and multiple causes of death, ICD-10. Hyattsville, MD: US Department of Health and Human Services, CDC, National Center for Health Statistics; 2020. https://www.cdc.gov/nchs/nvss/instruction-manuals.htm

    3.Heron M. Deaths: leading causes for 2017. Natl Vital Stat Rep 2019;68:1–77. PMID:32501203

    4.US Census Bureau. National population by characteristics: 2020–2021. Washington, DC: US Department of Commerce, US Census Bureau; 2021. https://www.census.gov/programs-surveys/popest/technical-documentation/research/evaluation-estimates/2020-evaluation-estimates/2010s-national-detail.html

    5.US Census Bureau. Methodology for the United States population estimates: vintage 2021. Washington, DC: US Department of Commerce, US Census Bureau; 2021. https://www2.census.gov/programs-surveys/popest/technical-documentation/methodology/2020-2021/methods-statement-v2021.pdf

    6.CDC. Medical examiners’ and coroners’ handbook on death registration and fetal death reporting, 2003 revision. Hyattsville, Maryland: US Department of Health and Human Services, CDC, National Center for Health Statistics; 2003. https://stacks.cdc.gov/view/cdc/6636

  3. Dec 31, 2020 · In June, incidence increased in all age groups, with the most rapid rate of increase and highest overall incidence among young adults aged 1824 years; the rate in this group continues to be the highest among all age groups. Incidence steadily increased among children and adolescents (aged 0–17 years).

  4. Coronavirus. By country. Data explorer. Deaths. Cases. Tests. Hospitalizations. Vaccinations. Mortality risk. Excess mortality. Policy responses. Contents. Our interactive data visualizations that show the case fatality rate in each country are updated daily. The text below is updated periodically.

  5. In 2020, the death rate for COVID-19 among those aged 65 and over increased with age. The rate for adults aged 85 and over (1,645.0) was 2.8 times higher than the rate for those aged 75–84 (589.8) and 7 times higher than that for age group 65–74 (234.3). How did age-adjusted COVID-19 death rates vary by race and ethnicity and

  6. Apr 29, 2022 · Details: Corporate Authors: National Center for Immunization and Respiratory Diseases (U.S.). Division of Viral Diseases. Description: Updated Apr. 29, 2022. All rates are relative to the 18- to 29-year-old age category.

  7. Feb 24, 2022 · The countries with the highest IFR on July 15, 2020, were Portugal (2·085%, 0·946–4·395), Monaco (1·778%, 1·265–2·915), Japan (1·750%, 1·302–2·690), Spain (1·710%, 0·991–2·718), and Greece (1·637%, 1·155–2·678). All-age IFR varied by a factor of more than 30 among 190 countries and territories.