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Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body. In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene.
CYP1A2 is the major hepatic isoform of the human CYP1A subfamily (Shimada et al., 1994). Studies suggest negligible to no detectible CYP1A2 mRNA or protein expression/activity during gestation (Hakkola et al., 1994). Postnatally, CYP1A2 is the last major CYP enzyme to fully mature (Berthou et al., 1988; Sonnier and Cresteil, 1998).
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Aug 1, 2023 · What is CYP1A2? CYP1A2 is part of the drug-metabolizing enzyme family, known as cytochrome P450. CYP1A2 plays an important role in the metabolism of several mental health medications, including duloxetine, fluvoxamine, clozapine, olanzapine, and mirtazapine.
Cytochrome P450, family 11, also known as CYP11, is a chordate cytochrome P450 monooxygenase family. This family contains many enzymes involved in steroidogenesis, such as Cholesterol side-chain cleavage enzyme (CYP11A1), Steroid 11β-hydroxylase (CYP11B1) and Aldosterone synthase (CYP11B2). [3] CYP11 can be divided into A to E five subfamilies ...
CYP1A2. CYP1A2 accounts for ∼15% of the hepatic P450 content and is the main clearance mechanism for clinically important drugs such as theophylline, caffeine, clozapine, olanzapine, tizanidine, duloxetine, and ramelteon.
Nov 26, 2018 · An exploratory analysis involving healthy nonsmoking non‐naïve caffeine drinkers (1–3 cups/day; 12 men, 12 women) administered caffeine (160 mg) on five occasions evaluated the effects of CYP1A2 induction status (based on genotype) and other factors on intraindividual variation in CYP 1A2 activity.
Jul 19, 2019 · CYP1A2 is a major cytochrome P450 (P450) which accounts for ∼12% of the total hepatic P450 content in humans (Iwatsubo et al., 1997; Achour et al., 2014). CYP1A2 substrates include drugs, industrial chemicals, and environmental toxicants.
