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Oct 29, 2020 · The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly identified as being able to induce in vitro the proliferation and differentiation of bone marrow progenitors into granulocytes and macrophages.
- Kevin M C Lee, Adrian A Achuthan, John A Hamilton
- 2020
Colony-stimulating factors in inflammation and autoimmunity. John A. Hamilton. Abstract | Although they were originally defined as haematopoietic-cell growth factors, colony-stimulating...
- John A. Hamilton
- 2008
Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of committed progenitors in the bone marrow, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell (usually white blood cells.
Key Points. Colony-stimulating factors (CSFs) — granulocyte/macrophage CSF (GM-CSF), macrophage CSF (M-CSF) and granulocyte CSF (G-CSF) — have wider functions than their original in vitro ...
- John A. Hamilton
- 2008
Apr 30, 2020 · Colony-stimulating factor 3 receptor (CSF3R) is a driver of neutrophil differentiation, proliferation, and activation following granulocyte colony-stimulating factor binding, resulting in downstream signaling of tyrosine kinases, including JAK/STAT and SRC. 1-3 Activating mutations in CSF3R are highly prevalent in chronic neutrophilic leukemia ...
- Katherine Tarlock, Katherine Tarlock, Todd Alonzo, Todd Alonzo, Yi Cheng Wang, Robert B. Gerbing, Rh...
- 2020
May 9, 2013 · We identified activating mutations in the gene encoding the receptor for colony-stimulating factor 3 (CSF3R) in 16 of 27 patients (59%) with CNL or atypical CML.
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Dec 25, 2011 · We combined genome-wide linkage analysis with exome sequencing and identified 14 different mutations affecting the tyrosine kinase domain of the colony stimulating factor 1 receptor (encoded by CSF1R) in 14 families with HDLS. In one kindred, we confirmed the de novo occurrence of the mutation.
