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May 1, 2024 · Direct infection and activation of platelets by dengue virus (DENV), by non-structural protein NS1 and high-density lipoprotein (HDL) complexes through TLR4, and by serotonin and platelet-activating factor (PAF) generated by mast cell degranulation, together lead to platelet activation, aggregation, and bleeding.
DENV infection leads to a loss of mitochondrial membrane integrity, which triggers the release of mitochondrial DNA into the cytosol, inducing the activation of the DNA sensor cGAS and, ultimately,...
- Michiel van Gent, Michaela U. Gack
- 2017
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Apr 1, 2022 · Understanding the molecular mechanisms of vector-virus interactions is likely to provide novel targets to be exploited for development of drugs and efficient control strategies. The siRNA mechanism of Aedes mosquitoes can be exploited to confer resistance to DENV in natural uninfected populations.
Apr 12, 2012 · There are an estimated 50 million infections per year with the dengue virus, which is transmitted primarily by urban-adapted Aedes aegypti mosquitoes. This review summarizes pathophysiology and tre...
Sep 3, 2021 · The lack of a suitable animal model, a proper mechanistic study in pathogenesis, and ADE are the main hindrances in vaccine development. This review summarizes the current knowledge on DENV epidemiology, biology, and disease aetiology in the context of prevention and protection from dengue virus disease.
- Sudipta Kumar Roy, Soumen Bhattacharjee
- 2021
Jan 15, 2023 · FcR-dependent ADE is the most common mechanism for a wide range of virus infection such as HIV, influenza A, dengue and Ebola. Cells which have FcR such as monocytes, B cells, neutrophils and macrophages are easily attached by the virus-antibody complexes because the Fc region of the antibody will bind on the cell surface with FcR which leads ...
Dengue virus (DENV), the causative agent of den- gue fever, is a mosquitoborne single-stranded RNA virus from the genus Flavivirus, often defined as 4 related serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) (1). Globally, ≈4 billion persons in 128 coun - tries are at risk for dengue fever (2).
