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Nov 24, 2020 · The exact mechanisms responsible for severe manifestations of dengue virus disease are not yet fully elucidated and are likely to be multifactorial. DENV infection can have diverse presentations in different hosts, which cannot be explained by a single hypothesis alone.
Knowledge of contemporary genetic composition of den- gue virus (DENV) in Africa is lacking. By using next-gen- eration sequencing of samples from the 2017 DENV out- break in Burkina Faso, we isolated 29 DENV genomes (5 serotype 1, 16 serotype 2 [DENV-2], and 8 serotype 3).
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May 1, 2024 · Direct infection and activation of platelets by dengue virus (DENV), by non-structural protein NS1 and high-density lipoprotein (HDL) complexes through TLR4, and by serotonin and platelet-activating factor (PAF) generated by mast cell degranulation, together lead to platelet activation, aggregation, and bleeding.
Jan 15, 2023 · FcR-dependent ADE is the most common mechanism for a wide range of virus infection such as HIV, influenza A, dengue and Ebola. Cells which have FcR such as monocytes, B cells, neutrophils and macrophages are easily attached by the virus-antibody complexes because the Fc region of the antibody will bind on the cell surface with FcR which leads ...
Sep 20, 2019 · Dengue virus (DENV) belongs to the family Flaviviridae, genus Flavivirus. It is a single-stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus includes other arthropod borne viruses such as yellow fever virus, West Nile virus, Zika virus, tick-borne encephalitis virus.
- Amudhan Murugesan, Mythreyee Manoharan
- 2020
- 10.1016/B978-0-12-819400-3.00016-8
Complex interplay of viral and host factors in pathogenesis of dengue virus infection. pathway, targeting liver cells which leads to the stimula-tion of inflammatory cytokines. This subsequently leads to plasma leakage and accumulation of fluid in third space, ultimately causing dengue shock syndrome [30].
Nature Microbiology, infection by dengue virus (DENV), which has an RNA genome, is shown to induce mitochondrial DNA release into the cytosol, leading to cGAS activation. In turn, DENV targets ...
