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1. www.ncbi.nlm.nih.gov › pmc › articlesCurrent Status of Dengue Therapeutics Research and Development

   www.ncbi.nlm.nih.gov › pmc › articles

   Mar 1, 2017 · Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue.

   • Table - PMC - National Center for Biotechnology Information

     List of Clinical Studies on Dengue Therapeutics. Compound...

   • Current Trends and Limitations in Dengue Antiviral Research

     Table 1 shows a list of compounds that target the dengue...

2. pubmed.ncbi.nlm.nih.gov › 34020338Dengue structural proteins as antiviral drug targets: Current ...

   pubmed.ncbi.nlm.nih.gov › 34020338

   Oct 5, 2021 · Antiviral Agents. Viral Structural Proteins. Dengue virus belongs to the class of RNA viruses and subclass of enveloped single-stranded positive-sense RNA virus. It causes dengue fever (DF), dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS), where DHF and DSS are life-threatening.

   • Author: Akshatha H. S, Gurubasavaraj V. Pujar, Arun Kumar Sethu, Meduri Bhagyalalitha, Manisha Singh

   • Publish Year: 2021

3. People also ask

   Which drugs are used in clinical trials for dengue?

   • The most recent proof-of-concept clinical trials for dengue have been performed using repurposed or off-patent drugs, namely chloroquine, prednisolone, balapiravir, celgosivir, and lovastatin (Table 1 ). These trials have all used the conventional double-blinded, randomized, placebo-controlled design with clearly defined primary end points.

   Current Status of Dengue Therapeutics Research and Development

   www.ncbi.nlm.nih.gov/pmc/articles/PMC5388029/

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   What are antiviral drug targets for dengue?

   • Antiviral drug targets for dengue The viral components of dengue can be targeted effectively to develop antiviral drugs classified as viral protein targets and viral enzyme targets. Viral protein targets can be sub-classified into structural and non-structural protein targets.

   Dengue structural proteins as antiviral drug targets: Current status in

   www.sciencedirect.com/science/article/pii/S0223523421003767

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   How many types of dengue virus are there?

   • Dengue virus has four different serotypes (DENV 1–4) based on structural antigens which induce type-specific antibodies upon infection [ 6 ]. A fifth serotype (DENV5), which is currently limited to only an outbreak in Sarawak, Malaysia, has also been identified [ 21, 22 ]; however, its genome sequence is yet to be reported.

   Current Trends and Limitations in Dengue Antiviral Research

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8544673/

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4. www.nature.com › articles › s41579/021/00538-3Pan-serotype antiviral for dengue infection | Nature Reviews ...

   www.nature.com › articles › s41579/021/00538-3

   Mar 1, 2021 · Antiviral drugs to specifically treat DENV infections are not currently available. In a new study, researchers at Novartis report the development of a small molecule that is effective against...

   • Author: Katie Kingwell
   • Email: nrmicro@nature.com

   • Publish Year: 2021

5. www.nature.com › articles › d41573/021/00036-4Pan-serotype antiviral for dengue infection - Nature

   www.nature.com › articles › d41573/021/00036-4

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   Feb 22, 2021 · 22 February 2021. Pan-serotype antiviral for dengue infection. By. Katie Kingwell. Dengue virus (DENV) is a mosquito-borne flavivirus that exists in four distinct serotypes and can cause...

   • Author: Katie Kingwell

   • Publish Year: 2021

6. www.sciencedirect.com › science › articleDengue structural proteins as antiviral drug targets: Current ...

   www.sciencedirect.com › science › article

   Oct 5, 2021 · Structural proteins are building blocks of viruses, targeting them to weaken the virus and eventually kills it. Therefore can be a promising drug target for treating dengue viral infections. •. Envelope proteins are one of the widely studied structural proteins and are the most promising anti-dengue drug target. •.

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8. pubmed.ncbi.nlm.nih.gov › 36992414Molecular Mechanisms of Antiviral Agents against Dengue Virus

   pubmed.ncbi.nlm.nih.gov › 36992414

   Mar 8, 2023 · Evaluations of combinations of antiviral drugs with different mechanisms of action could also lead to the development of synergistic drug combinations for the treatment of dengue at any stage of the infection. Keywords: antiviral; dengue virus; flavivirus; mechanism of action; peptide; phytochemicals; small molecule.