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1. www.ncbi.nlm.nih.gov › pmc › articlesCurrent Understanding of the Pathogenesis of Dengue Virus...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 24, 2020 · The exact mechanisms responsible for severe manifestations of dengue virus disease are not yet fully elucidated and are likely to be multifactorial. DENV infection can have diverse presentations in different hosts, which cannot be explained by a single hypothesis alone.

2. www.ncbi.nlm.nih.gov › pmc › articlesDengue Virus - PMC - National Center for Biotechnology ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 20, 2019 · Dengue virus (DENV) belongs to the family Flaviviridae, genus Flavivirus. It is a single-stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus includes other arthropod borne viruses such as yellow fever virus, West Nile virus, Zika virus, tick-borne encephalitis virus.

   • Author: Amudhan Murugesan, Mythreyee Manoharan
   • Published: 2020

   • DOI: 10.1016/B978-0-12-819400-3.00016-8

3. opendengue.org › dataOpenDengue: Data

   opendengue.org › data

   • Cached

   The OpenDengue dataset contains reported total case counts with each row corresponds to a unique location and time. Where reported, we include dengue cases at all levels of severity (dengue, dengue with/without warning signs, severe dengue, dengue haemorhaggic fever, dengue shock syndrome, dengue deaths) and methods of confirmation (suspected ...

4. www.ncbi.nlm.nih.gov › pmc › articlesProduction, Transmission, Pathogenesis, and Control of Dengue ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Dec 15, 2021 · Potential antiviral mechanism and molecular targets of the bioactive compounds inhibiting viral entry and replication of dengue virus. Infection of virus involves various stages: In the initial steps, DENV binds to cell receptors including mannose-binding receptor (MR) and DC-SIGN (dendritic cell-specific ICAM3 grabbing nonintegrin) receptor ...

   • DOI: 10.1155/2021/4224816
   • Published: 2021

   • Publication: Biomed Res Int. 2021; 2021: 4224816.

5. People also ask

   What factors are involved in the pathogenesis of dengue virus infection?

   • 1. Summary of various factors implicated in pathogenesis of dengue virus infection Higher viremia levels of DENV-2 and DENV-3 in secondary infections. Inhibits antiviral genes and enhancing the production of IL-10. Apart from various viral factors implicated in the pathogenesis of DENV infection, host genetic factors also play an important role.

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7815537/

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   Which proteins are involved in the pathogenesis of dengue virus?

   • Dengue virus genome encodes for three structural proteins (C, prM (M), and E) and seven non-structural (NS) proteins (NS1, NS2a, NS2B, NS3, NS4a, NS4B, and NS5). The most important non-structural protein which has been implicated in the pathogenesis of dengue viral infections is NS1 [ 23 ].

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7815537/

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   Does dengue virus infection trigger endothelial cell activation?

   • 107. Brown MG, Hermann LL, Issekutz AC, Marshall JS, Rowter D, Al-Afif A, et al. Dengue virus infection of mast cells triggers endothelial cell activation. J Virol. 2011;85(2):1145–1150. [ PMC free article] [ PubMed] [ Google Scholar] 108.

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7815537/

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6. www.sciencedirect.com › science › articleMolecular mechanisms in the pathogenesis of dengue infections

   www.sciencedirect.com › science › article

   May 1, 2024 · Direct infection and activation of platelets by dengue virus (DENV), by non-structural protein NS1 and high-density lipoprotein (HDL) complexes through TLR4, and by serotonin and platelet-activating factor (PAF) generated by mast cell degranulation, together lead to platelet activation, aggregation, and bleeding.

7. cdnsciencepub.com › doi › fullDengue virus: epidemiology, biology, and disease aetiology

   cdnsciencepub.com › doi › full

   Sep 3, 2021 · Dengue is a vector-borne viral disease caused by the flavivirus dengue virus (DENV). Approximately 400 million cases and 22 000 deaths occur due to dengue worldwide each year. It has been reported in more than 100 countries in tropical and subtropical regions. A positive-stranded enveloped RNA virus (DENV) is principally transmitted by Aedes mosquitoes. It has four antigenically distinct ...

8. www.nature.com › articles › s41467/019/09391-8Structure mapping of dengue and Zika viruses reveals ...

   www.nature.com › articles › s41467/019/09391-8

   Mar 29, 2019 · 37 Altmetric. Metrics. Dengue (DENV) and Zika (ZIKV) viruses are clinically important members of the Flaviviridae family with an 11 kb positive strand RNA genome that folds to enable virus...