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  1. Nov 24, 2020 · The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility.

  2. DEN Dengue DEN-1 Dengue virus serotype 1 DEN-2 Dengue virus serotype 2 DEN-3 Dengue virus serotype 3 DEN-4 Dengue virus serotype 4 DF Dengue fever DHF Dengue haemorrhagic fever DIVC Disseminated intravascular coagulopathy DSS Dengue shock syndrome DPG Diphosphoglycerate ECG Electrocardiogram

  3. Dec 15, 2021 · Potential antiviral mechanism and molecular targets of the bioactive compounds inhibiting viral entry and replication of dengue virus. Infection of virus involves various stages: In the initial steps, DENV binds to cell receptors including mannose-binding receptor (MR) and DC-SIGN (dendritic cell-specific ICAM3 grabbing nonintegrin) receptor ...

    • 10.1155/2021/4224816
    • 2021
    • Biomed Res Int. 2021; 2021: 4224816.
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  5. Sep 20, 2019 · Abstract. Dengue virus (DENV) belongs to the family Flaviviridae, genus Flavivirus. It is a single-stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus includes other arthropod borne viruses such as yellow fever virus, West Nile virus, Zika virus, tick-borne encephalitis virus.

    • Amudhan Murugesan, Mythreyee Manoharan
    • 2020
    • 10.1016/B978-0-12-819400-3.00016-8
  6. Sep 3, 2021 · Dengue is a vector-borne viral disease caused by the flavivirus dengue virus (DENV). Approximately 400 million cases and 22 000 deaths occur due to dengue worldwide each year. It has been reported in more than 100 countries in tropical and subtropical regions. A positive-stranded enveloped RNA virus (DENV) is principally transmitted by Aedes mosquitoes. It has four antigenically distinct ...

    • Sudipta Kumar Roy, Soumen Bhattacharjee
    • 2021
  7. Jan 15, 2023 · FcR-dependent ADE is the most common mechanism for a wide range of virus infection such as HIV, influenza A, dengue and Ebola. Cells which have FcR such as monocytes, B cells, neutrophils and macrophages are easily attached by the virus-antibody complexes because the Fc region of the antibody will bind on the cell surface with FcR which leads ...

  8. May 1, 2024 · HLH is characterized by macrophage activation, natural killer (NK) cell dysfunction and depletion, and aberrant T cell activation leading to a cytokine storm [ 122 ]. HLH leading to severe dengue is one of the most important challenges in managing patients with dengue because it is associated with high mortality.

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