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1. ncbi.nlm.nih.gov › pmc › articlesDengue: Update on Clinically Relevant Therapeutic Strategies and...

   ncbi.nlm.nih.gov › pmc › articles

   Apr 18, 2023 · There have been recent advances in the development of promising drugs for the treatment of dengue. These include direct antivirals that can reduce virus replication as well as host-targeted drugs for reducing inflammation and/or vascular pathologies.

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     Dengue viruses (DENV) continue to circulate worldwide,...

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     Clinical trials for dengue prophylaxis in healthy...

2. www.ncbi.nlm.nih.gov › pmc › articlesCurrent Trends and Limitations in Dengue Antiviral Research

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 30, 2021 · More in-depth characterization of the structure of the dengue NS5 protein and mechanistic insights into how it performs its multiple functions will strengthen drug discovery efforts geared towards NS5 as a target against the dengue virus.

   • Author: Juliet O Obi, Hernando Gutiérrez-Barbosa, Joel V Chua, Daniel J Deredge
   • DOI: 10.3390/tropicalmed6040180

   • Publish Year: 2021
   • Publication: Trop Med Infect Dis. 2021 Dec; 6(4): 180.

3. People also ask

   Could a new mechanism be used to design antiviral drugs for dengue?

   • Scientists have uncovered a new mechanism for designing antiviral drugs for dengue virus. A multidisciplinary team from The University of Texas Medical Branch at Galveston has uncovered a new mechanism for designing antiviral drugs for dengue virus. The study is currently available in Proceedings of the National Academy of Sciences.

   New antiviral mechanism for dengue therapeutics -- ScienceDaily

   www.sciencedaily.com/releases/2020/07/200713165556.htm

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   Are there antiviral agents against dengue?

   • Research efforts into the development of antiviral agents against dengue have intensified in the last few years since there are still no available treatments to date. Classical targets for the development of small molecule inhibitors include NS3 protease, NS3 helicase, NS4B, and NS5 proteins [ 64 ].

   Current Trends and Limitations in Dengue Antiviral Research

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8544673/

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   What is dengue antiviral drug discovery?

   • Dengue Antiviral Drug Discovery As a consequence of the high prevalence of dengue fever and the lack of a widely applicable vaccine, an efficient antiviral agent to treat DENV infection is urgently needed. By and large, there are two approaches to antiviral drug discovery.

   Updates on Dengue Vaccine and Antiviral: Where Are We Heading?

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8620506/

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4. pubmed.ncbi.nlm.nih.gov › 34020338Dengue structural proteins as antiviral drug targets: Current ...

   pubmed.ncbi.nlm.nih.gov › 34020338

   Oct 5, 2021 · In this review, the possible drug targets for discovery and development of potential antiviral drugs against structural proteins of dengue virus, the current development status of the antiviral drugs against dengue around the world, and challenges that need to be addressed to overcome the shortcomings in the process of drug discovery have been ...

   • Author: Akshatha H. S, Gurubasavaraj V. Pujar, Arun Kumar Sethu, Meduri Bhagyalalitha, Manisha Singh

   • Publish Year: 2021

5. www.ncbi.nlm.nih.gov › pmc › articlesUpdates on Dengue Vaccine and Antiviral: Where Are We Heading?

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 9, 2021 · The search for specific dengue inhibitors is expanding, and the mechanisms for evaluating the efficacy of novel drugs are currently established, allowing for expedited translation into human trials. Furthermore, in the aftermath of the only FDA-approved vaccine, Dengvaxia, a safer and more effective dengue vaccine candidate is making its way ...

   • Author: Harun Norshidah, Harun Norshidah, Ramachandran Vignesh, Ngit Shin Lai
   • DOI: 10.3390/molecules26226768

   • Publish Year: 2021
   • Publication: Molecules. 2021 Nov; 26(22): 6768.

6. www.nature.com › articles › d41586/021/02638-9A step towards therapeutics for dengue - Nature

   www.nature.com › articles › d41586/021/02638-9

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   Oct 6, 2021 · An effective drug against dengue virus (DENV) is urgently needed, because this mosquito-transmitted virus represents a tremendous public-health burden, with about 3.9 billion people at risk of ...

   • Author: Scott B. Biering, Eva Harris

   • Publish Year: 2021

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8. pubmed.ncbi.nlm.nih.gov › 36992414Molecular Mechanisms of Antiviral Agents against Dengue Virus

   pubmed.ncbi.nlm.nih.gov › 36992414

   Mar 8, 2023 · This review discusses the mechanisms of action employed by various antiviral agents against DENV. The development of host-directed antivirals targeting host receptors and direct-acting antivirals targeting DENV structural and non-structural proteins are reviewed.

9. www.sciencedaily.com › releases › 2020New antiviral mechanism for dengue therapeutics | ScienceDaily

   www.sciencedaily.com › releases › 2020

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   Jul 13, 2020 · July 13, 2020. Source: University of Texas Medical Branch at Galveston. Summary: Scientists have uncovered a new mechanism for designing antiviral drugs for dengue virus. Share: FULL STORY....