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Nov 24, 2020 · The present article reviews the current concepts of the various mechanisms involved in the pathogenesis of dengue virus infection and gives a comprehensive overview of the multiple factors responsible for severe clinical manifestations of the disease.
Dec 15, 2021 · Potential antiviral mechanism and molecular targets of the bioactive compounds inhibiting viral entry and replication of dengue virus. Infection of virus involves various stages: In the initial steps, DENV binds to cell receptors including mannose-binding receptor (MR) and DC-SIGN (dendritic cell-specific ICAM3 grabbing nonintegrin) receptor ...
- 10.1155/2021/4224816
- 2021
- Biomed Res Int. 2021; 2021: 4224816.
Fig. 1. Complex interplay of viral and host factors in pathogenesis of dengue virus infection. pathway, targeting liver cells which leads to the stimula-tion of inflammatory cytokines. This subsequently leads to plasma leakage and accumulation of fluid in third space, ultimately causing dengue shock syndrome [30].
- 1MB
- Puneet Bhatt, Sasidharan Pillai Sabeena, Muralidhar Varma, Govindakarnavar Arunkumar, Govindakarnava...
- 16
- 2021
Jan 15, 2023 · FcR-dependent ADE is the most common mechanism for a wide range of virus infection such as HIV, influenza A, dengue and Ebola. Cells which have FcR such as monocytes, B cells, neutrophils and macrophages are easily attached by the virus-antibody complexes because the Fc region of the antibody will bind on the cell surface with FcR which leads ...
doi:10.1038/nri3916. Dengue is a positive-sense RNA virus belonging to the Flaviviridae family. There are four distinct serotypes — dengue virus serotype 1 (DENV1) to DENV4 — and several ...
- Gavin Screaton, Juthathip Mongkolsapaya, Juthathip Mongkolsapaya, Sophie Yacoub, Sophie Yacoub, Cath...
- 2015
pathogenesis of severe dengue compared to many other infections such as COVID-19 [7]. In this review we discuss the molecular mechanisms of dengue pathogenesis and highlight recent developments and gaps in our knowledge which are important for the identification of dengue biomarkers and drug targets.
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Nov 19, 2023 · PDF / ePub. More. Abstract. Dengue is a viral infection caused by one of four serotypes of dengue virus (DENV), which is responsible for causing potentially life-threatening disease and substantial public health as well as economic burden worldwide.
