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1. www.ncbi.nlm.nih.gov › pmc › articlesCurrent Understanding of the Pathogenesis of Dengue Virus...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 24, 2020 · The present article reviews the current concepts of the various mechanisms involved in the pathogenesis of dengue virus infection and gives a comprehensive overview of the multiple factors responsible for severe clinical manifestations of the disease.

2. jbiomedsci.biomedcentral.com › articles › 10Dengue virus pathogenesis and host molecular machineries

   jbiomedsci.biomedcentral.com › articles › 10

   • Cached

   Apr 22, 2024 · Dengue virus infection is known to induce endoplasmic reticulum (ER) stress, triggering signaling pathways associated with ER stress during viral infections. These pathways activate genes that support cell survival and anti-viral defenses.

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4. www.ncbi.nlm.nih.gov › pmc › articlesProduction, Transmission, Pathogenesis, and Control of Dengue ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Dec 15, 2021 · Potential antiviral mechanism and molecular targets of the bioactive compounds inhibiting viral entry and replication of dengue virus. Infection of virus involves various stages: In the initial steps, DENV binds to cell receptors including mannose-binding receptor (MR) and DC-SIGN (dendritic cell-specific ICAM3 grabbing nonintegrin) receptor ...

   • DOI: 10.1155/2021/4224816
   • Published: 2021

   • Publication: Biomed Res Int. 2021; 2021: 4224816.

5. link.springer.com › content › pdfCurrent Understanding of the Pathogenesis of Dengue Virus ...

   link.springer.com › content › pdf

   Complex interplay of viral and host factors in pathogenesis of dengue virus infection. pathway, targeting liver cells which leads to the stimula-tion of inflammatory cytokines. This subsequently leads to plasma leakage and accumulation of fluid in third space, ultimately causing dengue shock syndrome [30].

   • File Size: 1MB
   • Author: Puneet Bhatt, Sasidharan Pillai Sabeena, Muralidhar Varma, Govindakarnavar Arunkumar, Govindakarnava...

   • Page Count: 16
   • Publish Year: 2021

6. www.cell.com › trends › molecular-medicineMolecular mechanisms in the pathogenesis of dengue infections

   www.cell.com › trends › molecular-medicine

   pathogenesis of severe dengue compared to many other infections such as COVID-19 [7]. In this review we discuss the molecular mechanisms of dengue pathogenesis and highlight recent developments and gaps in our knowledge which are important for the identification of dengue biomarkers and drug targets.

7. www.ncbi.nlm.nih.gov › pmc › articlesMolecular Mechanisms of Antiviral Agents against Dengue Virus

   www.ncbi.nlm.nih.gov › pmc › articles

   Mar 8, 2023 · Antiviral agents designed based on these molecular mechanisms of action could lead to the discovery and development of novel anti-DENV therapeutics for the treatment of dengue infections.

8. People also ask

   How does a dengue virus interact with the host cellular machinery?

   • During dengue infection, the virus interacts with the host cellular machinery responsible for 5’ capping. DENV employs multiple strategies to hijack and manipulate this process. For instance, the virus sequesters essential host factors involved in capping, such as the cap-binding complex and associated enzymes.

   Dengue virus pathogenesis and host molecular machineries

   jbiomedsci.biomedcentral.com/articles/10.1186/s12929-024-01030-9

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   What is the pathogenesis of dengue?

   • The pathogenesis of dengue was attributed to various viral and host factors such as non-structural protein 1 (NS1) viral antigen, DENV genome variation, subgenomic RNA, antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies and autoimmunity.

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7815537/

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   Which proteins are involved in the pathogenesis of dengue virus?

   • Dengue virus genome encodes for three structural proteins (C, prM (M), and E) and seven non-structural (NS) proteins (NS1, NS2a, NS2B, NS3, NS4a, NS4B, and NS5). The most important non-structural protein which has been implicated in the pathogenesis of dengue viral infections is NS1 [ 23 ].

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7815537/

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9. www.nature.com › articles › s41577/019/0123-xAdaptive immune responses to primary and secondary dengue ...

   www.nature.com › articles › s41577/019/0123-x

   Jan 24, 2019 · Dengue is a viral illness that is spread primarily by Aedes mosquitoes and infects ~390 million people each year worldwide 1.It is caused by dengue virus (DENV), which belongs to the family of ...